Microparticles to enhance delivery of drugs and growth factors into wound sites

Sanjeev Ranjan; Flavia Fontana; Hanif Ullah; Jouni Hirvonen; Hélder A. Santos

doi:10.4155/tde-2016-0039

Microparticles to enhance delivery of drugs and growth factors into wound sites

Sanjeev Ranjan^*, Flavia Fontana, Hanif Ullah, Jouni Hirvonen, Hélder A. Santos

^*Corresponding author for this work

Not published at Aalto University

University of Helsinki

Research output: Contribution to journal › Review Article › peer-review

13 Citations (Scopus)

Abstract

Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.

Original language	English
Pages (from-to)	711-732
Number of pages	22
Journal	Therapeutic Delivery
Volume	7
Issue number	10
DOIs	https://doi.org/10.4155/tde-2016-0039
Publication status	Published - Oct 2016
MoE publication type	A2 Review article, Literature review, Systematic review

Keywords

drugs
growth factors
microparticles
wound healing

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10.4155/tde-2016-0039

Cite this

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title = "Microparticles to enhance delivery of drugs and growth factors into wound sites",

abstract = "Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.",

keywords = "drugs, growth factors, microparticles, wound healing",

author = "Sanjeev Ranjan and Flavia Fontana and Hanif Ullah and Jouni Hirvonen and Santos, {H{\'e}lder A.}",

note = "Funding Information: HA Santos acknowledges financial support from the Academy of Finland (decisions no. 252215 and 281300), the University of Helsinki Research Funds, the Biocentrum Helsinki, and the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013, grant no. 310892). H Ullah acknowledges the Higher Education Commission of Pakistan. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2016 Future Science Ltd.",

year = "2016",

month = oct,

doi = "10.4155/tde-2016-0039",

language = "English",

volume = "7",

pages = "711--732",

journal = "Therapeutic Delivery",

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AU - Ranjan, Sanjeev

AU - Fontana, Flavia

AU - Ullah, Hanif

AU - Hirvonen, Jouni

AU - Santos, Hélder A.

N1 - Funding Information: HA Santos acknowledges financial support from the Academy of Finland (decisions no. 252215 and 281300), the University of Helsinki Research Funds, the Biocentrum Helsinki, and the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013, grant no. 310892). H Ullah acknowledges the Higher Education Commission of Pakistan. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © 2016 Future Science Ltd.

PY - 2016/10

Y1 - 2016/10

N2 - Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.

AB - Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.

KW - drugs

KW - growth factors

KW - microparticles

KW - wound healing

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SP - 711

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JO - Therapeutic Delivery

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ER -

Microparticles to enhance delivery of drugs and growth factors into wound sites

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Keywords

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