Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO

Iiro Kiiski*, Sanna Artes, Ville Jokinen, Päivi Järvinen, Tiina Sikanen

*Corresponding author for this work

Research output: Contribution to conferenceAbstractScientificpeer-review

Abstract

We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's metabolic clearance in vivo.

Original languageEnglish
Pages744-745
Number of pages2
Publication statusPublished - 2019
MoE publication typeNot Eligible
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019
Conference number: 23

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTAS
CountrySwitzerland
CityBasel
Period27/10/201931/10/2019

Keywords

  • Drug metabolism
  • Drug screening
  • Enzyme immobilization
  • Microreactors

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