Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

Nada Aljuaid; Jani Seitsonen; Janne Ruokolainen; Francesca Greco; Ian W. Hamley

doi:10.1021/acsomega.2c05940

Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

Nada Aljuaid
, Jani Seitsonen
, Janne Ruokolainen
, Francesca Greco
, Ian W. Hamley^*

^*Corresponding author for this work

University of Reading

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.

Original language	English
Pages (from-to)	46843-46848
Number of pages	6
Journal	ACS Omega
Volume	7
Issue number	50
DOIs	https://doi.org/10.1021/acsomega.2c05940
Publication status	Published - 20 Dec 2022
MoE publication type	A1 Journal article-refereed

Funding

N.A. acknowledges support from the Saudi Arabian Cultural Bureau. I.W.H. thanks EPSRC for the award of an Established Career Fellowship (ref EP/V053396/1). We thank Diamond Light Source for the award of beamtime (ref sm28659-1 and -2) and Barbara Gerbelli (FAPESP-funded visiting postdoc at University of Reading), Nathan Cowieson (Diamond), and Katsuaki Inoue (Diamond) for assistance with the SAXS measurements. We are grateful to Az Alddien Natfji (University of Reading) for help with cell assays.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell CytotoxicityFinal published version, 4.41 MBLicence: CC BY

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@article{335b0abe54df46fe87a37614e479b2b1,

title = "Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity",

abstract = "Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.",

author = "Nada Aljuaid and Jani Seitsonen and Janne Ruokolainen and Francesca Greco and Hamley, \{Ian W.\}",

note = "Funding Information: N.A. acknowledges support from the Saudi Arabian Cultural Bureau. I.W.H. thanks EPSRC for the award of an Established Career Fellowship (ref EP/V053396/1). We thank Diamond Light Source for the award of beamtime (ref sm28659-1 and -2) and Barbara Gerbelli (FAPESP-funded visiting postdoc at University of Reading), Nathan Cowieson (Diamond), and Katsuaki Inoue (Diamond) for assistance with the SAXS measurements. We are grateful to Az Alddien Natfji (University of Reading) for help with cell assays. Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",

year = "2022",

month = dec,

day = "20",

doi = "10.1021/acsomega.2c05940",

language = "English",

volume = "7",

pages = "46843--46848",

journal = "ACS Omega",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

AU - Aljuaid, Nada

AU - Seitsonen, Jani

AU - Ruokolainen, Janne

AU - Greco, Francesca

AU - Hamley, Ian W.

N1 - Funding Information: N.A. acknowledges support from the Saudi Arabian Cultural Bureau. I.W.H. thanks EPSRC for the award of an Established Career Fellowship (ref EP/V053396/1). We thank Diamond Light Source for the award of beamtime (ref sm28659-1 and -2) and Barbara Gerbelli (FAPESP-funded visiting postdoc at University of Reading), Nathan Cowieson (Diamond), and Katsuaki Inoue (Diamond) for assistance with the SAXS measurements. We are grateful to Az Alddien Natfji (University of Reading) for help with cell assays. Publisher Copyright: © 2022 American Chemical Society.

PY - 2022/12/20

Y1 - 2022/12/20

N2 - Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.

AB - Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.

UR - https://www.scopus.com/pages/publications/85143871928

U2 - 10.1021/acsomega.2c05940

DO - 10.1021/acsomega.2c05940

M3 - Article

AN - SCOPUS:85143871928

SN - 2470-1343

VL - 7

SP - 46843

EP - 46848

JO - ACS Omega

JF - ACS Omega

IS - 50

ER -

Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

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Funding

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Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

Abstract

Funding

UN SDGs

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Other files and links

Fingerprint

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OtaNano

OtaNano - Nanomicroscopy Center

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