@inproceedings{1a4a8da6acd4406e8d74fdb2ef00ee31,
title = "MHz ultrasonic drive-in: Localized drug delivery for osteoarthritis therapy",
abstract = "Osteoarthritis (OA) is a significant musculoskeletal disease with no cure. Current drug delivery techniques feature poor spatial localization (systemic delivery or injection into the synovial capsule). We previously used kHz high-intensity ultrasound to deliver micro- and nano-particles into articular cartilage (AC). Here we investigated whether MHz ultrasound can deliver particles into AC. Using high-intensity focused ultrasound (HIFU) we drove agents into 45% depth of the AC thickness. In addition, laser-induced shock waves showed drive-in effect. Our results demonstrate that MHz ultrasound can locally administer agents into AC. The technique could potentially be used for localized OA drug therapy.",
keywords = "Articular cartilage, Drug delivery, High intensity focused ultrasound, Laser-ultrasound, Osteoarthritis",
author = "Nieminen, {Heikki J.} and Ari Salmi and Jari Rinta-Aho and Geoffrey Hubbel and Kimmo Wjuga and Suuronen, {Jussi Petteri} and Ritva Serimaa and Edward Haeggstrom",
year = "2013",
doi = "10.1109/ULTSYM.2013.0160",
language = "English",
isbn = "9781467356862",
series = "IEEE International Ultrasonics Symposium",
publisher = "IEEE",
pages = "619--622",
booktitle = "2013 IEEE International Ultrasonics Symposium, IUS 2013",
note = "IEEE International Ultrasonics Symposium, IUS ; Conference date: 21-07-2013 Through 25-07-2013",
}