MHz ultrasonic drive-in: Localized drug delivery for osteoarthritis therapy

Heikki J. Nieminen*, Ari Salmi, Jari Rinta-Aho, Geoffrey Hubbel, Kimmo Wjuga, Jussi Petteri Suuronen, Ritva Serimaa, Edward Haeggstrom

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

5 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a significant musculoskeletal disease with no cure. Current drug delivery techniques feature poor spatial localization (systemic delivery or injection into the synovial capsule). We previously used kHz high-intensity ultrasound to deliver micro- and nano-particles into articular cartilage (AC). Here we investigated whether MHz ultrasound can deliver particles into AC. Using high-intensity focused ultrasound (HIFU) we drove agents into 45% depth of the AC thickness. In addition, laser-induced shock waves showed drive-in effect. Our results demonstrate that MHz ultrasound can locally administer agents into AC. The technique could potentially be used for localized OA drug therapy.

Original languageEnglish
Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
Pages619-622
Number of pages4
DOIs
Publication statusPublished - 2013
MoE publication typeA4 Conference publication
EventIEEE International Ultrasonics Symposium - Prague, Czech Republic
Duration: 21 Jul 201325 Jul 2013

Publication series

NameIEEE International Ultrasonics Symposium
PublisherIEEE
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

ConferenceIEEE International Ultrasonics Symposium
Abbreviated titleIUS
Country/TerritoryCzech Republic
CityPrague
Period21/07/201325/07/2013

Keywords

  • Articular cartilage
  • Drug delivery
  • High intensity focused ultrasound
  • Laser-ultrasound
  • Osteoarthritis

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