TY - JOUR
T1 - Mechanism of adsorption of actives onto microporous functionalised calcium carbonate (FCC)
AU - Levy, Charlotte L.
AU - Matthews, Graham Peter
AU - Laudone, Giuliano M.
AU - Beckett, Samuel
AU - Turner, Andrew
AU - Schoelkopf, Joachim
AU - Gane, Patrick A.C.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Microporous ‘functionalised’ calcium carbonate (FCC) has potential for use as a carrier for the controlled release of ‘actives’, by permeation and diffusion. We have investigated the nature of the FCC surface and the mechanism of adsorption of two typical actives, namely the anti-inflammatory drug aspirin and the flavour compound vanillin, from chloroform and aqueous ethanolic solutions. There is indirect evidence from the quantitative perturbation of Tóth isotherms that their adsorption is hindered by a stagnant diffusion layer of water trapped in the micro-porosity of the FCC. To complement previous studies of the surface of FCC, it was also tested with the cationic probe benzyltrimethylammonium bromide and the anionic probe sodium 2-naphthalenesulphonate. Experimental procedures were validated by comparison with adsorption onto ground calcium carbonate and high surface area talc.
AB - Microporous ‘functionalised’ calcium carbonate (FCC) has potential for use as a carrier for the controlled release of ‘actives’, by permeation and diffusion. We have investigated the nature of the FCC surface and the mechanism of adsorption of two typical actives, namely the anti-inflammatory drug aspirin and the flavour compound vanillin, from chloroform and aqueous ethanolic solutions. There is indirect evidence from the quantitative perturbation of Tóth isotherms that their adsorption is hindered by a stagnant diffusion layer of water trapped in the micro-porosity of the FCC. To complement previous studies of the surface of FCC, it was also tested with the cationic probe benzyltrimethylammonium bromide and the anionic probe sodium 2-naphthalenesulphonate. Experimental procedures were validated by comparison with adsorption onto ground calcium carbonate and high surface area talc.
KW - Aspirin
KW - Controlled drug delivery
KW - Controlled flavour release
KW - Functionalised calcium carbonate (FCC)
KW - Vanillin
UR - http://www.scopus.com/inward/record.url?scp=85018816322&partnerID=8YFLogxK
U2 - 10.1007/s10450-017-9880-7
DO - 10.1007/s10450-017-9880-7
M3 - Article
AN - SCOPUS:85018816322
VL - 23
SP - 603
EP - 612
JO - ADSORPTION : JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
JF - ADSORPTION : JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
SN - 0929-5607
IS - 4
ER -