Mechanism of adsorption of actives onto microporous functionalised calcium carbonate (FCC)

Charlotte L. Levy, Graham Peter Matthews, Giuliano M. Laudone, Samuel Beckett, Andrew Turner, Joachim Schoelkopf, Patrick A.C. Gane

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)


Microporous ‘functionalised’ calcium carbonate (FCC) has potential for use as a carrier for the controlled release of ‘actives’, by permeation and diffusion. We have investigated the nature of the FCC surface and the mechanism of adsorption of two typical actives, namely the anti-inflammatory drug aspirin and the flavour compound vanillin, from chloroform and aqueous ethanolic solutions. There is indirect evidence from the quantitative perturbation of Tóth isotherms that their adsorption is hindered by a stagnant diffusion layer of water trapped in the micro-porosity of the FCC. To complement previous studies of the surface of FCC, it was also tested with the cationic probe benzyltrimethylammonium bromide and the anionic probe sodium 2-naphthalenesulphonate. Experimental procedures were validated by comparison with adsorption onto ground calcium carbonate and high surface area talc.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
Issue number4
Publication statusPublished - 1 May 2017
MoE publication typeA1 Journal article-refereed


  • Aspirin
  • Controlled drug delivery
  • Controlled flavour release
  • Functionalised calcium carbonate (FCC)
  • Vanillin

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