Measurements of [11C]CO2 in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [11C]acetate

Hannu T. Sipila; Sven Johan Heselius; Matti K. Kalliokoski; Jukka Kemppainen; Heikki Minn; Tuula Tolvanen; Anne Roivainen

doi:10.1109/NSSMIC.2011.6152653

Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate

Hannu T. Sipila^*, Sven Johan Heselius, Matti K. Kalliokoski, Jukka Kemppainen, Heikki Minn, Tuula Tolvanen, Anne Roivainen

^*Corresponding author for this work

Not published at Aalto University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

Abstract

A positron-sensitive, large-window single-wire proportional counter was used for measurements of [¹¹C]CO₂ in exhaled air after i.v. injection of [¹¹C]acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into the measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [¹¹C]CO₂ in the air exhaled by patients after i.v. injection of an ¹¹C-labelled radiopharmaceutical. The limit of detection was 200 Bq/L for [ ¹¹C]CO₂.

Original language	English
Title of host publication	2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
Publisher	IEEE
Pages	2397-2399
Number of pages	3
ISBN (Print)	9781467301183
DOIs	https://doi.org/10.1109/NSSMIC.2011.6152653
Publication status	Published - 1 Jan 2011
MoE publication type	A4 Article in a conference publication
Event	IEEE Nuclear Science Symposium and Medical Imaging Conference - Valencia, Spain Duration: 23 Oct 2011 → 29 Oct 2011

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Conference

Conference	IEEE Nuclear Science Symposium and Medical Imaging Conference
Abbreviated title	NSS/MIC
Country	Spain
City	Valencia
Period	23/10/2011 → 29/10/2011

Access to Document

10.1109/NSSMIC.2011.6152653

Link to publication in Scopus

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Sipila, H. T., Heselius, S. J., Kalliokoski, M. K., Kemppainen, J., Minn, H., Tolvanen, T., & Roivainen, A. (2011). Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate. In 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 (pp. 2397-2399). [6152653] (IEEE Nuclear Science Symposium Conference Record). IEEE. https://doi.org/10.1109/NSSMIC.2011.6152653

Sipila, Hannu T. ; Heselius, Sven Johan ; Kalliokoski, Matti K. ; Kemppainen, Jukka ; Minn, Heikki ; Tolvanen, Tuula ; Roivainen, Anne. / Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate. 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011. IEEE, 2011. pp. 2397-2399 (IEEE Nuclear Science Symposium Conference Record).

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title = "Measurements of [11C]CO2 in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [11C]acetate",

abstract = "A positron-sensitive, large-window single-wire proportional counter was used for measurements of [11C]CO2 in exhaled air after i.v. injection of [11C]acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into the measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [11C]CO2 in the air exhaled by patients after i.v. injection of an 11C-labelled radiopharmaceutical. The limit of detection was 200 Bq/L for [ 11C]CO2.",

author = "Sipila, {Hannu T.} and Heselius, {Sven Johan} and Kalliokoski, {Matti K.} and Jukka Kemppainen and Heikki Minn and Tuula Tolvanen and Anne Roivainen",

year = "2011",

month = jan,

day = "1",

doi = "10.1109/NSSMIC.2011.6152653",

language = "English",

isbn = "9781467301183",

series = "IEEE Nuclear Science Symposium Conference Record",

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pages = "2397--2399",

booktitle = "2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011",

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note = "IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC ; Conference date: 23-10-2011 Through 29-10-2011",

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Sipila, HT, Heselius, SJ, Kalliokoski, MK, Kemppainen, J, Minn, H, Tolvanen, T & Roivainen, A 2011, Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate. in 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011., 6152653, IEEE Nuclear Science Symposium Conference Record, IEEE, pp. 2397-2399, IEEE Nuclear Science Symposium and Medical Imaging Conference, Valencia, Spain, 23/10/2011. https://doi.org/10.1109/NSSMIC.2011.6152653

Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate. / Sipila, Hannu T.; Heselius, Sven Johan; Kalliokoski, Matti K.; Kemppainen, Jukka; Minn, Heikki; Tolvanen, Tuula; Roivainen, Anne.

2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011. IEEE, 2011. p. 2397-2399 6152653 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

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AU - Roivainen, Anne

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AB - A positron-sensitive, large-window single-wire proportional counter was used for measurements of [11C]CO2 in exhaled air after i.v. injection of [11C]acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into the measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [11C]CO2 in the air exhaled by patients after i.v. injection of an 11C-labelled radiopharmaceutical. The limit of detection was 200 Bq/L for [ 11C]CO2.

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Sipila HT, Heselius SJ, Kalliokoski MK, Kemppainen J, Minn H, Tolvanen T et al. Measurements of [¹¹C]CO₂ in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [¹¹C]acetate. In 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011. IEEE. 2011. p. 2397-2399. 6152653. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2011.6152653