Magnetic actuation of flexible microelectrode arrays for neural activity recordings

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Lei Gao
  • Jinfen Wang
  • Shouliang Guan
  • Mingde Du

  • Kun Wu
  • Ke Xu
  • Liang Zou
  • Huihui Tian
  • Ying Fang

Research units

  • Chinese Academy of Sciences
  • University of Chinese Academy of Sciences
  • CAS - Institute of Mechanics
  • Chinese Academy of Sciences
  • University of Chinese Academy of Sciences

Abstract

Implantable microelectrodes that can be remotely actuated via external fields are promising tools to interface with biological systems at a high degree of precision. Here, we report the development of flexible magnetic microelectrodes (FMμEs) that can be remotely actuated by magnetic fields. The FMμEs consist of flexible microelectrodes integrated with dielectrically encapsulated FeNi (iron-nickel) alloy microactuators. Both magnetic torque- and force-driven actuation of the FMμEs have been demonstrated. Nano-platinum coated FMµEs have been applied for in vivo recordings of neural activities from peripheral nerves and cerebral cortex of mice. Moreover, owing to their ultra-small sizes and mechanical compliance with neural tissues, chronically implanted FMµEs elicited greatly reduced neuronal cell loss in mouse brain compared to conventional stiff probes. The FMµEs open up a variety of new opportunities for electrically interfacing with biological systems in a controlled and minimally-invasive manner.

Details

Original languageEnglish
JournalNano Letters
Publication statusE-pub ahead of print - 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • Flexible microelectrode, magnetic actuation, nanoscale roughness, neural recording, inflammatory response

ID: 37483520