Machine learning and feature selection for drug response prediction in precision oncology applications

Mehreen Ali, Tero Aittokallio*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

41 Citations (Scopus)
74 Downloads (Pure)

Abstract

In-depth modeling of the complex interplay among multiple omics data measured from cancer cell lines or patient tumors is providing new opportunities toward identification of tailored therapies for individual cancer patients. Supervised machine learning algorithms are increasingly being applied to the omics profiles as they enable integrative analyses among the high-dimensional data sets, as well as personalized predictions of therapy responses using multi-omics panels of response-predictive biomarkers identified through feature selection and cross-validation. However, technical variability and frequent missingness in input “big data” require the application of dedicated data preprocessing pipelines that often lead to some loss of information and compressed view of the biological signal. We describe here the state-of-the-art machine learning methods for anti-cancer drug response modeling and prediction and give our perspective on further opportunities to make better use of high-dimensional multi-omics profiles along with knowledge about cancer pathways targeted by anti-cancer compounds when predicting their phenotypic responses.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalBiophysical Reviews
Volume11
Issue number1
DOIs
Publication statusPublished - 7 Feb 2019
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Drug response prediction
  • Feature selection
  • Multi-view regression
  • Omics profiling
  • Precision oncology
  • Predictive biomarkers

Fingerprint Dive into the research topics of 'Machine learning and feature selection for drug response prediction in precision oncology applications'. Together they form a unique fingerprint.

Cite this