Abstract
Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.
| Original language | English |
|---|---|
| Article number | 5363 |
| Number of pages | 15 |
| Journal | Nature Communications |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Oct 2020 |
| MoE publication type | A1 Journal article-refereed |
Funding
This study was supported by the Academy of Finland (J.M.P., project numbers: 253130, 256472, 281414, 296304, 266745; S.P., 266402, 266745, 303933, 325404), by the Juselius Foundation (J.M.P., S.P.), by the Helsinki University Research Funds (J.M.P., S.P.), and by the Finnish Cultural Foundation (G.A., 12938). The research leading to these results has received funding from the European Union Seventh Framework Program (FP7/2007-2013, J.M.P., S.P.) under grant agreement no. 604102 (Human Brain Project). G.A. was partially funded by Fondazione San Paolo (20670).