Long-range phase synchronization of high-frequency oscillations in human cortex

G. Arnulfo*, S. H. Wang, V. Myrov, Benedetta Toselli, Jonni Hirvonen, M. M. Fato, L. Nobili, F. Cardinale, Annalisa Rubino, A. Zhigalov, S. Palva, J. M. Palva

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
132 Downloads (Pure)

Abstract

Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.

Original languageEnglish
Article number5363
Number of pages15
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 23 Oct 2020
MoE publication typeA1 Journal article-refereed

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