Lipase-Induced Oxidative Furan Rearrangements

Fabian Blume, Petra Sprengart, Jan Deska

Research output: Contribution to journalArticleScientificpeer-review

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Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines.

Original languageEnglish
Pages (from-to)1293-1296
Number of pages4
Issue number10
Publication statusPublished - 15 Jan 2018
MoE publication typeA1 Journal article-refereed


  • Achmatowicz
  • furan
  • heterocyclic chemistry
  • pyranone
  • ring expansion
  • synthetic methodology

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  • Projects

    Beyond Biosynthesis: Enzymes as Catalysts in Non-natural Synthetic Transformations

    Blume, F., Jäger, C., Deska, J., Naapuri, J., Liu, Y. & Kiefer, A.


    Project: Academy of Finland: Other research funding


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