Lipase-Induced Oxidative Furan Rearrangements

Fabian Blume, Petra Sprengart, Jan Deska

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)
112 Downloads (Pure)

Abstract

Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines.

Original languageEnglish
Pages (from-to)1293-1296
Number of pages4
JournalSynlett
Volume29
Issue number10
DOIs
Publication statusPublished - 15 Jan 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • Achmatowicz
  • furan
  • heterocyclic chemistry
  • pyranone
  • ring expansion
  • synthetic methodology

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