Lipase-catalyzed linear aliphatic polyester synthesis in organic solvent

Yu-Yen Linko, Zhuo-Lin Wang, Jukka Seppälä

    Research output: Contribution to journalArticleScientificpeer-review

    86 Citations (Scopus)

    Abstract

    Enzymatic polymerization of bis(2,2,2-trifluoroethyl) sebacate and aliphatic diols was investigated with the purpose of obtaining a polyester of as high as possible average molecular weight. The reaction was carried out at 37°C, and vacuum was applied to shift the equilibrium forward by removal of the 2,2,2-trifluoroethanol formed. The results showed that the elimination of alcohol formed was critical for a high degree of polymerization. Among the four lipases studied, Mucor miehei lipase was the best biocatalyst for polytransesterification and diphenyl ether was the best solvent for the polymerization of bis(2,2,2-trifluoroethyl) sebacate with 1,4-butanediol. The highest average molecular weight (Mw) of 46,400 g mol-1 (degree of polymerization = 184) was obtained when 0.51 m (187 g l-1) bis(2,2,2-trifluoroethyl) sebacate was polymerized with 0.51 m (46 g l-1) 1,4-butanediol in diphenyl ether for 168 h (7 days) with 36.5% M. miehei lipase powder.

    Original languageEnglish
    Pages (from-to)506-511
    Number of pages6
    JournalEnzyme and Microbial Technology
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - 1995
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Aliphatic diol
    • aliphatic linear polyester
    • bis(2,2,2-trifluoroethyl) sebacate
    • enzymic polymerization
    • lipase
    • organic solvent
    • polytransesterification

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