Light activated liposomes: Functionality and prospects in ocular drug delivery

Tatu Lajunen, Riikka Nurmi, Leena Kontturi, Lauri Viitala, Marjo Yliperttula, Lasse Murtomäki, Arto Urtti*

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    39 Citations (Scopus)

    Abstract

    Ocular drug delivery, especially to the retina and choroid, is a major challenge in drug development. Liposome technology may be useful in ophthalmology in enabling new routes of delivery, prolongation of drug action and intracellular drug delivery, but drug release from the liposomes should be controlled. For that purpose, light activation may be an approach to release drug at specified time and site in the eye. Technical advances have been made in the field of light activated drug release, particularly indocyanine green loaded liposomes are a promising approach with safe materials and effective light triggered release of small and large molecules. This review discusses the liposomal drug delivery with light activated systems in the context of ophthalmic drug delivery challenges.

    Original languageEnglish
    Pages (from-to)157–166
    JournalJournal of Controlled Release
    Volume244
    Issue numberPart B
    Early online date6 Jul 2016
    DOIs
    Publication statusPublished - Dec 2016
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Drug release
    • Light activation
    • Liposome
    • Ocular drug delivery
    • Posterior segment
    • Retina
    • Thermosensitive

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  • Cite this

    Lajunen, T., Nurmi, R., Kontturi, L., Viitala, L., Yliperttula, M., Murtomäki, L., & Urtti, A. (2016). Light activated liposomes: Functionality and prospects in ocular drug delivery. Journal of Controlled Release, 244(Part B), 157–166. https://doi.org/10.1016/j.jconrel.2016.08.024