Leak-Resistant Design of DNA Strand Displacement Systems

Vinay Gautam*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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Although a number of dynamically-controlled nanostructures and programmable DNA Strand Displacement (DSD) systems have been designed using DNA strand displacement, predictability and scalability of these DNA-based systems remain limited due to leakages introduced by spuriously triggered displacement events. We present a systematic design method for implementing leak-resistant DNA strand displacement systems in which each legitimate displacement event requires signal species to bind cooperatively at the two designated toehold binding sites in the protected fuel complexes, and thus inhibits spurious displacement events. To demonstrate the potential of the leak-resistant design approach for the construction of arbitrary complex digital circuits and systems with analog behaviors, we present domain-level designs and displacement pathways of the basic building blocks of the DNA strand displacement cascades, e.g. OR, AND gates, and an elementary bimolecular reaction.

Original languageEnglish
Title of host publicationBio-inspired Information and Communication Technologies - 12th EAI International Conference, BICT 2020, Proceedings
EditorsYifan Chen, Tadashi Nakano, Lin Lin, Mohammad Upal Mahfuz, Weisi Guo
Number of pages17
ISBN (Print)9783030571146
Publication statusPublished - 2020
MoE publication typeA4 Conference publication
EventInternational Conference on Bio-inspired Information and Communications Technologies - Shanghai, China
Duration: 7 Jul 20208 Jul 2020
Conference number: 12

Publication series

NameLecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST
Volume329 LNICST
ISSN (Print)1867-8211


ConferenceInternational Conference on Bio-inspired Information and Communications Technologies
Abbreviated titleBICT


  • DNA Strand Displacement
  • Dynamic DNA Nanotechnology
  • Leak-resistant
  • Leakages
  • Leakless


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