TY - JOUR
T1 - Language mapping in healthy volunteers and brain tumor patients with a novel navigated TMS system
T2 - Evidence of tumor-induced plasticity
AU - Rösler, J.
AU - Niraula, B.
AU - Strack, V.
AU - Zdunczyk, A.
AU - Schilt, S.
AU - Savolainen, Petri
AU - Lioumis, P.
AU - Mäkelä, J.
AU - Vajkoczy, P.
AU - Frey, D.
AU - Picht, T.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Objective: This article explores the feasibility of a novel repetitive navigated transcranial magnetic stimulation (rnTMS) system and compares language mapping results obtained by rnTMS in healthy volunteers and brain tumor patients. Methods: Fifteen right-handed healthy volunteers and 50 right-handed consecutive patients with left-sided gliomas were examined with a picture-naming task combined with time-locked rnTMS (5-10. Hz and 80-120% resting motor threshold) applied over both hemispheres. Induced errors were classified into four psycholinguistic types and assigned to their respective cortical areas according to the coil position during stimulation. Results: In healthy volunteers, language disturbances were almost exclusively induced in the left hemisphere. In patients errors were more frequent and induced at a comparative rate over both hemispheres. Predominantly dysarthric errors were induced in volunteers, whereas semantic errors were most frequent in the patient group. Conclusion: The right hemisphere's increased sensitivity to rnTMS suggests reorganization in language representation in brain tumor patients. Significance: rnTMS is a novel technology for exploring cortical language representation. This study proves the feasibility and safety of rnTMS in patients with brain tumor.
AB - Objective: This article explores the feasibility of a novel repetitive navigated transcranial magnetic stimulation (rnTMS) system and compares language mapping results obtained by rnTMS in healthy volunteers and brain tumor patients. Methods: Fifteen right-handed healthy volunteers and 50 right-handed consecutive patients with left-sided gliomas were examined with a picture-naming task combined with time-locked rnTMS (5-10. Hz and 80-120% resting motor threshold) applied over both hemispheres. Induced errors were classified into four psycholinguistic types and assigned to their respective cortical areas according to the coil position during stimulation. Results: In healthy volunteers, language disturbances were almost exclusively induced in the left hemisphere. In patients errors were more frequent and induced at a comparative rate over both hemispheres. Predominantly dysarthric errors were induced in volunteers, whereas semantic errors were most frequent in the patient group. Conclusion: The right hemisphere's increased sensitivity to rnTMS suggests reorganization in language representation in brain tumor patients. Significance: rnTMS is a novel technology for exploring cortical language representation. This study proves the feasibility and safety of rnTMS in patients with brain tumor.
KW - Brain tumors
KW - Hemispheric dominance
KW - Language mapping
KW - Language plasticity
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=84894331936&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2013.08.015
DO - 10.1016/j.clinph.2013.08.015
M3 - Article
C2 - 24051073
AN - SCOPUS:84894331936
SN - 1388-2457
VL - 125
SP - 526
EP - 536
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 3
ER -