Ionic current inversion in pressure-driven polymer translocation through nanopores

S. Buyukdagli, R. Blossey, Tapio Ala-Nissila

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)
333 Downloads (Pure)


We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.
Original languageEnglish
Article number088303
Pages (from-to)1-5
JournalPhysical Review Letters
Issue number8
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed


  • charged liquid
  • polymer translocation


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