TY - JOUR
T1 - Investigation of solid–liquid equilibrium of stevioside in different pure and binary mix solvents at various temperatures
AU - Asadzadeh, Behnaz
AU - Liu, Bingbing
AU - Yan, Weidong
N1 - Funding Information:
Y.H. thanks the Natural Sciences and Engineering Research Council of Canada for a Discovery grant and a Discovery Accelerator grant. Funding from Canada Research Chair program is also acknowledged.
Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors thank the Department of Chemistry, Zhejiang University, for providing the necessary facilities to complete this work.
Publisher Copyright:
© 2019, Canadian Science Publishing. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The solubility of stevioside (a natural sweetener) in 12 pure solvents (methanol, 1-propanol, 2-propanol, 1-buthanol, 2-buthanol, 1-pentanol, 2-pentanol, 2-ethoxyethanol, 2-propoxyethanol, 2-buthoxyethanol, water, and acetone) and in binary mixed solvents (2-ethoxyethanol + water) have been determined using high performance liquid chromatography (HPLC) method at temperatures ranging from 288.15 to 328.15 K and atmospheric pressure. From the experimental data, it was found that the solubility increased with the rising temperature in all selected solvents. The experimental data for the solubility of stevioside were correlated with Apelblat and non-random two-liquid (NRTL) models. It was found that the Apelblat model has the better quality in fitting the solubility data. Also, thermodynamic functions of dissolution, mixing and transfer process were calculated by the van’t Hoff equation. Furthermore, the crystal habits of stevioside in selected solvents were studied.
AB - The solubility of stevioside (a natural sweetener) in 12 pure solvents (methanol, 1-propanol, 2-propanol, 1-buthanol, 2-buthanol, 1-pentanol, 2-pentanol, 2-ethoxyethanol, 2-propoxyethanol, 2-buthoxyethanol, water, and acetone) and in binary mixed solvents (2-ethoxyethanol + water) have been determined using high performance liquid chromatography (HPLC) method at temperatures ranging from 288.15 to 328.15 K and atmospheric pressure. From the experimental data, it was found that the solubility increased with the rising temperature in all selected solvents. The experimental data for the solubility of stevioside were correlated with Apelblat and non-random two-liquid (NRTL) models. It was found that the Apelblat model has the better quality in fitting the solubility data. Also, thermodynamic functions of dissolution, mixing and transfer process were calculated by the van’t Hoff equation. Furthermore, the crystal habits of stevioside in selected solvents were studied.
KW - Apelblat equation
KW - NRTL model
KW - Solubility
KW - Stevioside
KW - Thermodynamic properties
UR - http://www.scopus.com/inward/record.url?scp=85075332848&partnerID=8YFLogxK
U2 - 10.1139/cjc-2019-0232
DO - 10.1139/cjc-2019-0232
M3 - Article
AN - SCOPUS:85075332848
SN - 0008-4042
VL - 97
SP - 815
EP - 823
JO - Canadian Journal of Chemistry
JF - Canadian Journal of Chemistry
IS - 12
ER -