Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis

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Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis. / Bawuah, Prince; Karttunen, Anssi Pekka; Markl, Daniel; Ridgway, Cathy; Korhonen, Ossi; Gane, Patrick; Zeitler, J. Axel; Ketolainen, Jarkko; Peiponen, Kai Erik.

In: International Journal of Pharmaceutics, Vol. 544, No. 1, 10.06.2018, p. 278-284.

Research output: Contribution to journalArticleScientificpeer-review

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Bawuah, Prince ; Karttunen, Anssi Pekka ; Markl, Daniel ; Ridgway, Cathy ; Korhonen, Ossi ; Gane, Patrick ; Zeitler, J. Axel ; Ketolainen, Jarkko ; Peiponen, Kai Erik. / Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis. In: International Journal of Pharmaceutics. 2018 ; Vol. 544, No. 1. pp. 278-284.

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@article{f179e36ae1b941a6837aece8b5c92916,
title = "Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis",
abstract = "Heckel analysis is a widely used method for the characterisation of the compression behaviour of pharmaceutical samples during the preparation of solid dosage formulations. The present study introduces an optical version of the Heckel equation that is based on a combination of the conventional Heckel equation together with the linear relationship defined between the effective terahertz (THz) refractive index and the porosity of pharmaceutical tablets. The proposed optical Heckel equation allows us to, firstly, calculate the zero-porosity refractive index, and, secondly, predict the in-die development of the effective refractive index as a function of the compressive pressure during tablet compression. This was demonstrated for five batches of highly porous functionalised calcium carbonate (FCC) excipient compacts. The close match observed between the estimated in-die effective refractive index and the measured/out-of-die effective THz refractive index supports the validity of the proposed form of the equation. By comparing the measured and estimated in-die tablet properties, a clear change in the porosity and hence, the effective refractive index, due to post-compression elastic relaxation of the FCC compacts, has been observed. We have, therefore, proposed a THz-based compaction setup that will permit in-line monitoring of processes during tablet compression. We envisage that this new approach in tracking powder properties introduced in this preliminary study will lead to the onset of further extensive and detailed future studies.",
keywords = "Elastic relaxation, Heckel law, Pharmaceutical tablet, Porosity, Terahertz refractive index",
author = "Prince Bawuah and Karttunen, {Anssi Pekka} and Daniel Markl and Cathy Ridgway and Ossi Korhonen and Patrick Gane and Zeitler, {J. Axel} and Jarkko Ketolainen and Peiponen, {Kai Erik}",
year = "2018",
month = "6",
day = "10",
doi = "10.1016/j.ijpharm.2018.04.043",
language = "English",
volume = "544",
pages = "278--284",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1",

}

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TY - JOUR

T1 - Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis

AU - Bawuah, Prince

AU - Karttunen, Anssi Pekka

AU - Markl, Daniel

AU - Ridgway, Cathy

AU - Korhonen, Ossi

AU - Gane, Patrick

AU - Zeitler, J. Axel

AU - Ketolainen, Jarkko

AU - Peiponen, Kai Erik

PY - 2018/6/10

Y1 - 2018/6/10

N2 - Heckel analysis is a widely used method for the characterisation of the compression behaviour of pharmaceutical samples during the preparation of solid dosage formulations. The present study introduces an optical version of the Heckel equation that is based on a combination of the conventional Heckel equation together with the linear relationship defined between the effective terahertz (THz) refractive index and the porosity of pharmaceutical tablets. The proposed optical Heckel equation allows us to, firstly, calculate the zero-porosity refractive index, and, secondly, predict the in-die development of the effective refractive index as a function of the compressive pressure during tablet compression. This was demonstrated for five batches of highly porous functionalised calcium carbonate (FCC) excipient compacts. The close match observed between the estimated in-die effective refractive index and the measured/out-of-die effective THz refractive index supports the validity of the proposed form of the equation. By comparing the measured and estimated in-die tablet properties, a clear change in the porosity and hence, the effective refractive index, due to post-compression elastic relaxation of the FCC compacts, has been observed. We have, therefore, proposed a THz-based compaction setup that will permit in-line monitoring of processes during tablet compression. We envisage that this new approach in tracking powder properties introduced in this preliminary study will lead to the onset of further extensive and detailed future studies.

AB - Heckel analysis is a widely used method for the characterisation of the compression behaviour of pharmaceutical samples during the preparation of solid dosage formulations. The present study introduces an optical version of the Heckel equation that is based on a combination of the conventional Heckel equation together with the linear relationship defined between the effective terahertz (THz) refractive index and the porosity of pharmaceutical tablets. The proposed optical Heckel equation allows us to, firstly, calculate the zero-porosity refractive index, and, secondly, predict the in-die development of the effective refractive index as a function of the compressive pressure during tablet compression. This was demonstrated for five batches of highly porous functionalised calcium carbonate (FCC) excipient compacts. The close match observed between the estimated in-die effective refractive index and the measured/out-of-die effective THz refractive index supports the validity of the proposed form of the equation. By comparing the measured and estimated in-die tablet properties, a clear change in the porosity and hence, the effective refractive index, due to post-compression elastic relaxation of the FCC compacts, has been observed. We have, therefore, proposed a THz-based compaction setup that will permit in-line monitoring of processes during tablet compression. We envisage that this new approach in tracking powder properties introduced in this preliminary study will lead to the onset of further extensive and detailed future studies.

KW - Elastic relaxation

KW - Heckel law

KW - Pharmaceutical tablet

KW - Porosity

KW - Terahertz refractive index

UR - http://www.scopus.com/inward/record.url?scp=85046445352&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2018.04.043

DO - 10.1016/j.ijpharm.2018.04.043

M3 - Article

VL - 544

SP - 278

EP - 284

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 21281404