Interhemispheric synchrony in the neonatal EEG revisited: Activation synchrony index as a promising classifier

Ninah Koolen*, Anneleen Dereymaeker, Okko Räsänen, Katrien Jansen, Jan Vervisch, Vladimir Matic, Maarten De Vos, Sabine Van Huffel, Gunnar Naulaers, Sampsa Vanhatalo

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)
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Abstract

A key feature of normal neonatal EEG at term age is interhemispheric synchrony (IHS), which refers to the temporal co-incidence of bursting across hemispheres during trace alternant EEG activity. The assessment of IHS in both clinical and scientific work relies on visual, qualitative EEG assessment without clearly quantifiable definitions. A quantitative measure, activation synchrony index (ASI), was recently shown to perform well as compared to visual assessments. The present study was set out to test whether IHS is stable enough for clinical use, and whether it could be an objective feature of EEG normality. We analyzed 31 neonatal EEG recordings that had been clinically classified as normal (n = 14) or abnormal (n = 17) using holistic, conventional visual criteria including amplitude, focal differences, qualitative synchrony, and focal abnormalities. We selected 20-min epochs of discontinuous background pattern. ASI values were computed separately for different channel pair combinations and window lengths to define them for the optimal ASI intraindividual stability. Finally, ROC curves were computed to find trade-offs related to compromised data lengths, a common challenge in neonatal EEG studies. Using the average of four consecutive 2.5-min epochs in the centro-occipital bipolar derivations gave ASI estimates that very accurately distinguished babies clinically classified as normal vs. abnormal. It was even possible to draw a cut-off limit (ASI~3.6) which correctly classified the EEGs in 97% of all cases. Finally, we showed that compromising the length of EEG segments from 20 to 5 min leads to increased variability in ASI-based classification. Our findings support the prior literature that IHS is an important feature of normal neonatal brain function. We show that ASI may provide diagnostic value even at individual level, which strongly supports its use in prospective clinical studies on neonatal EEG as well as in the feature set of upcoming EEG classifiers.

Original languageEnglish
Article number1030
Pages (from-to)1-9
JournalFRONTIERS IN HUMAN NEUROSCIENCE
Volume8
DOIs
Publication statusPublished - 23 Dec 2014
MoE publication typeA1 Journal article-refereed

Keywords

  • Biomarker
  • Brain monitoring
  • Interhemispheric synchrony
  • Neonatal EEG
  • Preterm infant

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    Koolen, N., Dereymaeker, A., Räsänen, O., Jansen, K., Vervisch, J., Matic, V., De Vos, M., Van Huffel, S., Naulaers, G., & Vanhatalo, S. (2014). Interhemispheric synchrony in the neonatal EEG revisited: Activation synchrony index as a promising classifier. FRONTIERS IN HUMAN NEUROSCIENCE, 8, 1-9. [1030]. https://doi.org/10.3389/fnhum.2014.01030