Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond

Petteri Piskunen, Rosalind Latham, Christopher E. West, Matteo Castronovo*, Veikko Linko*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

6 Citations (Scopus)
15 Downloads (Pure)


Precise genome editing with CRISPR/Cas paves the way for many biochemical, biotechnological, and medical applications, and consequently, it may enable treatment of already known and still-to-be-found genetic diseases. Meanwhile, another rapidly emerging field—structural DNA nanotechnology—provides a customizable and modular platform for accurate positioning of nanoscopic materials, for e.g., biomedical uses. This addressability has just recently been applied in conjunction with the newly developed gene engineering tools to enable impactful, programmable nanotechnological applications. As of yet, self-assembled DNA nanostructures have been mainly employed to enhance and direct the delivery of CRISPR/Cas, but lately the groundwork has also been laid out for other intriguing and complex functions. These recent advances will be described in this perspective.

Original languageEnglish
Article number104389
Number of pages12
Issue number6
Early online date22 May 2022
Publication statusPublished - 17 Jun 2022
MoE publication typeA2 Review article in a scientific journal


  • Genetics
  • Nanostructure
  • Nanotechnology


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