Insights into the evaporation kinetics of indomethacin solutions

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Insights into the evaporation kinetics of indomethacin solutions. / Hellstén, S.; Han, B.; Mäkilä, Ermei; Niemi, Harri; Salonen, Jarno; Lehto, Vesa-Pekka; Stelzer, Torsten; Louhi-Kultanen, Marjatta; Ulrich, Joachim.

In: Chemical Engineering and Technology, Vol. 36, No. 8, 08.2013, p. 1300-1306.

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Hellstén, S. ; Han, B. ; Mäkilä, Ermei ; Niemi, Harri ; Salonen, Jarno ; Lehto, Vesa-Pekka ; Stelzer, Torsten ; Louhi-Kultanen, Marjatta ; Ulrich, Joachim. / Insights into the evaporation kinetics of indomethacin solutions. In: Chemical Engineering and Technology. 2013 ; Vol. 36, No. 8. pp. 1300-1306.

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@article{34a590543e6c4741bf78d46f9d402534,
title = "Insights into the evaporation kinetics of indomethacin solutions",
abstract = "Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100°C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.",
keywords = "Crystallization, Evaporation, Pharmaceutical products",
author = "S. Hellst{\'e}n and B. Han and Ermei M{\"a}kil{\"a} and Harri Niemi and Jarno Salonen and Vesa-Pekka Lehto and Torsten Stelzer and Marjatta Louhi-Kultanen and Joachim Ulrich",
year = "2013",
month = "8",
doi = "10.1002/ceat.201200718",
language = "English",
volume = "36",
pages = "1300--1306",
journal = "Chemical Engineering and Technology",
issn = "0930-7516",
publisher = "Wiley-VCH Verlag",
number = "8",

}

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TY - JOUR

T1 - Insights into the evaporation kinetics of indomethacin solutions

AU - Hellstén, S.

AU - Han, B.

AU - Mäkilä, Ermei

AU - Niemi, Harri

AU - Salonen, Jarno

AU - Lehto, Vesa-Pekka

AU - Stelzer, Torsten

AU - Louhi-Kultanen, Marjatta

AU - Ulrich, Joachim

PY - 2013/8

Y1 - 2013/8

N2 - Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100°C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.

AB - Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100°C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.

KW - Crystallization

KW - Evaporation

KW - Pharmaceutical products

UR - http://www.scopus.com/inward/record.url?scp=84880957504&partnerID=8YFLogxK

U2 - 10.1002/ceat.201200718

DO - 10.1002/ceat.201200718

M3 - Article

VL - 36

SP - 1300

EP - 1306

JO - Chemical Engineering and Technology

JF - Chemical Engineering and Technology

SN - 0930-7516

IS - 8

ER -

ID: 3352365