Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production

Emmanuelle Castagnoli; M.A.  Andersson; Raimo Mikkola; Laszlo Kredics; Tamás Marik; Jarek Kurnitski; Heidi Salonen

Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production

Emmanuelle Castagnoli, M.A. Andersson, Raimo Mikkola, Laszlo Kredics, Tamás Marik, Jarek Kurnitski, Heidi Salonen

Department of Civil Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Professional

Abstract

Chaetomium-like fungi growing on indoor building materials produce toxic substances. Fourteen toxigenic indoor Chaetomium-like isolates from buildings in Finland where investigated. Six Chaetomium globosum-like strains from indoor dusts were toxic with boar sperm assay and cytotoxic to porcine kidney cells (PK-15), emitted green fluorescence and produced chaetoglobosins inhibiting cellular glucose transport. OT7 and OT7b strains fromindoor dust were cytotoxic to PK-15 cells, non fluorescent and produced the extremely cytotoxic protein synthesis inhibitor, chaetomin. The six Chaetomium globosum-like strains were resistant to borax and very sensitive to the wetting agent genapol used in cleaning chemicals. This may indicate that indoor Chaetomium-like fungi occupy their own ecological niche in buildings.

Original language	English
Title of host publication	Sisäilmastoseminaari 2017, Helsinki, 15.03.2017
Editors	Jorma Säteri, Mervi Ahola
Publisher	Sisäilmayhdistys ry
Pages	227-232
Volume	35
ISBN (Print)	978-952-5236-45-3
Publication status	Published - 15 Mar 2017
MoE publication type	D3 Professional conference proceedings
Event	Sisäilmastoseminaari - Messukeskus, Helsinki, Finland Duration: 15 Mar 2017 → 15 Mar 2017 http://www.sisailmayhdistys.fi/Tapahtumat/Sisailmastoseminaarit/Sisailmastoseminaari-2017

Publication series

Name	SIY raportti 35
Publisher	Sisäilmayhdistys ry
ISSN (Print)	1237-1866

Conference

Conference	Sisäilmastoseminaari
Country	Finland
City	Helsinki
Period	15/03/2017 → 15/03/2017
Internet address	http://www.sisailmayhdistys.fi/Tapahtumat/Sisailmastoseminaarit/Sisailmastoseminaari-2017

Keywords

Chaetomium-like

Access to Document

http://www.sisailmayhdistys.fi/Tapahtumat/Sisailmastoseminaarit/Sisailmastoseminaari-2017

Fingerprint Dive into the research topics of 'Indoor <i>chaetomium</i>-like isolates: resistance to chemicals, fluorescence and mycotoxin production'. Together they form a unique fingerprint.

1 Finished

Toxin transport mechanisms from moisture damaged structures to indoor air
Castagnoli, E., Kurnitski, J., Mikkola, R., Ahmed, K., Piironen, J., Andersson, A., Vornanen-Winqvist, C., Salonen, H., Alapieti, T. & Taebnia, M.
01/09/2015 → 31/08/2019
Project: Academy of Finland: Other research funding

Cite this

Castagnoli, Emmanuelle ; Andersson, M.A. ; Mikkola, Raimo ; Kredics, Laszlo ; Marik, Tamás ; Kurnitski, Jarek ; Salonen, Heidi. / Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production. Sisäilmastoseminaari 2017, Helsinki, 15.03.2017. editor / Jorma Säteri ; Mervi Ahola. Vol. 35 Sisäilmayhdistys ry, 2017. pp. 227-232 (SIY raportti 35).

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abstract = "Chaetomium-like fungi growing on indoor building materials produce toxic substances. Fourteen toxigenic indoor Chaetomium-like isolates from buildings in Finland where investigated. Six Chaetomium globosum-like strains from indoor dusts were toxic with boar sperm assay and cytotoxic to porcine kidney cells (PK-15), emitted green fluorescence and produced chaetoglobosins inhibiting cellular glucose transport. OT7 and OT7b strains fromindoor dust were cytotoxic to PK-15 cells, non fluorescent and produced the extremely cytotoxic protein synthesis inhibitor, chaetomin. The six Chaetomium globosum-like strains were resistant to borax and very sensitive to the wetting agent genapol used in cleaning chemicals. This may indicate that indoor Chaetomium-like fungi occupy their own ecological niche in buildings.",

keywords = "Chaetomium-like",

author = "Emmanuelle Castagnoli and M.A. Andersson and Raimo Mikkola and Laszlo Kredics and Tam{\'a}s Marik and Jarek Kurnitski and Heidi Salonen",

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editor = "Jorma S{\"a}teri and Mervi Ahola",

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note = "Sis{\"a}ilmastoseminaari ; Conference date: 15-03-2017 Through 15-03-2017",

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Castagnoli, E , Andersson, MA , Mikkola, R, Kredics, L, Marik, T, Kurnitski, J & Salonen, H 2017, Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production. in J Säteri & M Ahola (eds), Sisäilmastoseminaari 2017, Helsinki, 15.03.2017. vol. 35, SIY raportti 35, Sisäilmayhdistys ry, pp. 227-232, Sisäilmastoseminaari, Helsinki, Finland, 15/03/2017.

Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production. / Castagnoli, Emmanuelle ; Andersson, M.A. ; Mikkola, Raimo; Kredics, Laszlo; Marik, Tamás; Kurnitski, Jarek ; Salonen, Heidi.

Sisäilmastoseminaari 2017, Helsinki, 15.03.2017. ed. / Jorma Säteri; Mervi Ahola. Vol. 35 Sisäilmayhdistys ry, 2017. p. 227-232 (SIY raportti 35).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Professional

TY - GEN

T1 - Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production

AU - Castagnoli, Emmanuelle

AU - Andersson, M.A.

AU - Mikkola, Raimo

AU - Kredics, Laszlo

AU - Marik, Tamás

AU - Kurnitski, Jarek

AU - Salonen, Heidi

PY - 2017/3/15

Y1 - 2017/3/15

N2 - Chaetomium-like fungi growing on indoor building materials produce toxic substances. Fourteen toxigenic indoor Chaetomium-like isolates from buildings in Finland where investigated. Six Chaetomium globosum-like strains from indoor dusts were toxic with boar sperm assay and cytotoxic to porcine kidney cells (PK-15), emitted green fluorescence and produced chaetoglobosins inhibiting cellular glucose transport. OT7 and OT7b strains fromindoor dust were cytotoxic to PK-15 cells, non fluorescent and produced the extremely cytotoxic protein synthesis inhibitor, chaetomin. The six Chaetomium globosum-like strains were resistant to borax and very sensitive to the wetting agent genapol used in cleaning chemicals. This may indicate that indoor Chaetomium-like fungi occupy their own ecological niche in buildings.

AB - Chaetomium-like fungi growing on indoor building materials produce toxic substances. Fourteen toxigenic indoor Chaetomium-like isolates from buildings in Finland where investigated. Six Chaetomium globosum-like strains from indoor dusts were toxic with boar sperm assay and cytotoxic to porcine kidney cells (PK-15), emitted green fluorescence and produced chaetoglobosins inhibiting cellular glucose transport. OT7 and OT7b strains fromindoor dust were cytotoxic to PK-15 cells, non fluorescent and produced the extremely cytotoxic protein synthesis inhibitor, chaetomin. The six Chaetomium globosum-like strains were resistant to borax and very sensitive to the wetting agent genapol used in cleaning chemicals. This may indicate that indoor Chaetomium-like fungi occupy their own ecological niche in buildings.

KW - Chaetomium-like

UR - http://www.sisailmayhdistys.fi/Tapahtumat/Sisailmastoseminaarit/Sisailmastoseminaari-2017

M3 - Conference contribution

SN - 978-952-5236-45-3

VL - 35

T3 - SIY raportti 35

SP - 227

EP - 232

BT - Sisäilmastoseminaari 2017, Helsinki, 15.03.2017

A2 - Säteri, Jorma

A2 - Ahola, Mervi

PB - Sisäilmayhdistys ry

T2 - Sisäilmastoseminaari

Y2 - 15 March 2017 through 15 March 2017

ER -

Indoor chaetomium-like isolates: resistance to chemicals, fluorescence and mycotoxin production

Abstract

Publication series

Conference

Keywords

Access to Document

Toxin transport mechanisms from moisture damaged structures to indoor air

Cite this