In vitro cytotoxicity and surface topography evaluation of additive manufacturing titanium implant materials

Jukka Tuomi, Roy Björkstrand, Mikael Pernu, Mika Salmi, Eero Huotilainen, Jan Wolff, Pekka Vallittu, Antti Mäkitie

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)
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Abstract

Custom-designed patient-specific implants and reconstruction plates are to date commonly manufactured using two different additive manufacturing (AM) technologies: direct metal laser sintering (DMLS) and electron beam melting (EBM). The purpose of this investigation was to characterize the surface structure and to assess the cytotoxicity of titanium alloys processed using DMLS and EBM technologies as the existing information on these issues is scarce. “Processed” and “polished” DMLS and EBM disks were assessed. Microscopic examination revealed titanium alloy particles and surface flaws on the processed materials. These surface flaws were subsequently removed by polishing. Surface roughness of EBM processed titanium was higher than that of DMLS processed. The cytotoxicity results of the DMLS and EBM discs were compared with a “gold standard” commercially available titanium mandible reconstruction plate. The mean cell viability for all discs was 82.6% (range, 77.4 to 89.7) and 83.3% for the control reconstruction plate. The DMLS and EBM manufactured titanium plates were non-cytotoxic both in “processed” and in “polished” forms.
Original languageEnglish
Article number53
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume28
Issue number3
Early online date2017
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

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