In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

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In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination. / Pigliacelli, Claudia; Sanjeeva, Kavitha Buntara; Nonappa; Pizzi, Andrea; Gori, Alessandro; Bombelli, Francesca Baldelli; Metrangolo, Pierangelo.

In: ACS Nano, Vol. 13, No. 2, 10.01.2019, p. 2158–2166.

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Pigliacelli, Claudia ; Sanjeeva, Kavitha Buntara ; Nonappa ; Pizzi, Andrea ; Gori, Alessandro ; Bombelli, Francesca Baldelli ; Metrangolo, Pierangelo. / In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination. In: ACS Nano. 2019 ; Vol. 13, No. 2. pp. 2158–2166.

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@article{d5325ac07b7d4e8ba8567889e2b93282,
title = "In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination",
abstract = "Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.",
keywords = "chiroptical, gold, iodine, nanoparticles, peptide, superstructures",
author = "Claudia Pigliacelli and Sanjeeva, {Kavitha Buntara} and Nonappa and Andrea Pizzi and Alessandro Gori and Bombelli, {Francesca Baldelli} and Pierangelo Metrangolo",
note = "| openaire: EC/H2020/789815/EU//MINIRES doi: 10.1021/acsnano.8b08805",
year = "2019",
month = "1",
day = "10",
doi = "10.1021/acsnano.8b08805",
language = "English",
volume = "13",
pages = "2158–2166",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "AMERICAN CHEMICAL SOCIETY",
number = "2",

}

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TY - JOUR

T1 - In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

AU - Pigliacelli, Claudia

AU - Sanjeeva, Kavitha Buntara

AU - Nonappa, null

AU - Pizzi, Andrea

AU - Gori, Alessandro

AU - Bombelli, Francesca Baldelli

AU - Metrangolo, Pierangelo

N1 - | openaire: EC/H2020/789815/EU//MINIRES doi: 10.1021/acsnano.8b08805

PY - 2019/1/10

Y1 - 2019/1/10

N2 - Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.

AB - Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.

KW - chiroptical

KW - gold

KW - iodine

KW - nanoparticles

KW - peptide

KW - superstructures

UR - http://www.scopus.com/inward/record.url?scp=85060365189&partnerID=8YFLogxK

U2 - 10.1021/acsnano.8b08805

DO - 10.1021/acsnano.8b08805

M3 - Article

VL - 13

SP - 2158

EP - 2166

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 2

ER -

ID: 31248958