In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)
146 Downloads (Pure)

Abstract

Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.

Original languageEnglish
Pages (from-to)2158–2166
Number of pages9
JournalACS Nano
Volume13
Issue number2
Early online date10 Jan 2019
DOIs
Publication statusPublished - 10 Jan 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • chiroptical
  • gold
  • iodine
  • nanoparticles
  • peptide
  • superstructures

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  • Projects

    HYBER: The Academy of Finland's Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials research (2014-2019)

    Cherian, T., Nonappa, N., Ikkala, O., Bertula, K., Poutanen, M., Morits, M., Hynninen, V., Myllymäki, T., Toivonen, M., Sohrabi, F., Haataja, J., Sanchez Sanchez, A. & Rissanen, S.

    01/01/201730/06/2020

    Project: Academy of Finland: Other research funding

    Equipment

    OtaNano

    Anna Rissanen (Manager)

    Aalto University

    Facility/equipment: Facility

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