Improved utilization of frequency-domain data for optical tomographic imaging of the human brain

Pauliina Hirvi; Ilkka Nissilä; Ambika Maria; Qianqian Fang; Kalle Kotilahti; Juha Heiskala; Jetro J. Tuulari; Linnea Karlsson; Antti Hannukainen; Hasse Karlsson; Nuutti Hyvönen

doi:10.1117/12.2649042

Improved utilization of frequency-domain data for optical tomographic imaging of the human brain

Pauliina Hirvi^*, Ilkka Nissilä, Ambika Maria, Qianqian Fang, Kalle Kotilahti, Juha Heiskala, Jetro J. Tuulari, Linnea Karlsson, Antti Hannukainen, Hasse Karlsson, Nuutti Hyvönen

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

56 Downloads (Pure)

Abstract

Frequency-domain (FD) optical tomography instruments modulate the intensity of the light source at a radio frequency and measure the amplitude and phase shift of the detected photon density wave. The differing spatial sensitivities of amplitude and phase to the optical properties of tissue suggest that inclusion of phase data can improve the image reconstruction accuracy. This study describes our methodology for improved use of FD data in conjunction with a Monte Carlo (MC) forward solver (Monte Carlo eXtreme; MCX) and a voxel-based model of a two-year-old child’s head. The child participated our previous study where subjects were stimulated with affective (slow brushing) and non-affective touch (fast brushing) to their right forearm, and the responses were measured from the left hemisphere with our in-house 16-channel high-density FD system. We implemented the computation of the FD sensitivity profiles to the MCX photon simulation software, and validated the output against our in-house MC code. We used simulated and the real experimental touch response data to observe the effects of including both FD data types to the image reconstruction instead of amplitude data alone. For the simulated and experimental case, we observed that the inclusion of phase data increases the reconstructed contrast in the brain. The individual touch responses showed similarity to the group-level results in our original publication with 16 subjects and amplitude data alone, and other literature.

Original language	English
Title of host publication	Optical Tomography and Spectroscopy of Tissue XV
Editors	Sergio Fantini, Paola Taroni
Publisher	SPIE
Pages	1-12
Number of pages	12
ISBN (Electronic)	9781510658578
DOIs	https://doi.org/10.1117/12.2649042
Publication status	Published - 2023
MoE publication type	A4 Conference publication
Event	Optical Tomography and Spectroscopy of Tissue - San Francisco, United States Duration: 30 Jan 2023 → 1 Feb 2023 Conference number: 15

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	SPIE
Volume	12376
ISSN (Print)	1605-7422

Conference

Conference	Optical Tomography and Spectroscopy of Tissue
Country/Territory	United States
City	San Francisco
Period	30/01/2023 → 01/02/2023

Keywords

Affective touch
Atlas model
Diffuse optical tomography
Frequency-domain
Image reconstruction
Monte Carlo
Regularization
Toddler brain

Access to Document

10.1117/12.2649042

Improved utilization of frequency-domain data for optical tomographic imaging of the human brain Final published version, 866 KB

Cite this

Hirvi, P., Nissilä, I., Maria, A., Fang, Q., Kotilahti, K., Heiskala, J., Tuulari, J. J., Karlsson, L., Hannukainen, A., Karlsson, H., & Hyvönen, N. (2023). Improved utilization of frequency-domain data for optical tomographic imaging of the human brain. In S. Fantini, & P. Taroni (Eds.), Optical Tomography and Spectroscopy of Tissue XV (pp. 1-12). Article 123760A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12376). SPIE. https://doi.org/10.1117/12.2649042

@inproceedings{dca2048851f2478f904e3d905c8125c2,

title = "Improved utilization of frequency-domain data for optical tomographic imaging of the human brain",

abstract = "Frequency-domain (FD) optical tomography instruments modulate the intensity of the light source at a radio frequency and measure the amplitude and phase shift of the detected photon density wave. The differing spatial sensitivities of amplitude and phase to the optical properties of tissue suggest that inclusion of phase data can improve the image reconstruction accuracy. This study describes our methodology for improved use of FD data in conjunction with a Monte Carlo (MC) forward solver (Monte Carlo eXtreme; MCX) and a voxel-based model of a two-year-old child{\textquoteright}s head. The child participated our previous study where subjects were stimulated with affective (slow brushing) and non-affective touch (fast brushing) to their right forearm, and the responses were measured from the left hemisphere with our in-house 16-channel high-density FD system. We implemented the computation of the FD sensitivity profiles to the MCX photon simulation software, and validated the output against our in-house MC code. We used simulated and the real experimental touch response data to observe the effects of including both FD data types to the image reconstruction instead of amplitude data alone. For the simulated and experimental case, we observed that the inclusion of phase data increases the reconstructed contrast in the brain. The individual touch responses showed similarity to the group-level results in our original publication with 16 subjects and amplitude data alone, and other literature.",

keywords = "Affective touch, Atlas model, Diffuse optical tomography, Frequency-domain, Image reconstruction, Monte Carlo, Regularization, Toddler brain",

author = "Pauliina Hirvi and Ilkka Nissil{\"a} and Ambika Maria and Qianqian Fang and Kalle Kotilahti and Juha Heiskala and Tuulari, {Jetro J.} and Linnea Karlsson and Antti Hannukainen and Hasse Karlsson and Nuutti Hyv{\"o}nen",

note = "Funding Information: We acknowledge the computational resources provided by the Aalto Science-IT project. Many thanks to the families participating the FinnBrain Birth Cohort Study. We also appreciate the following sources of funding: The Vilho, Yrj{\"o} and Kalle V{\"a}is{\"a}l{\"a} Foundation of the Finnish Academy of Science and Letters (grant numbers 190017 and 200015 (to PH)), Academy of Finland (decisions 336788 and 336789 (to AH, NH and PH); 269282 (to IN); 273451 and 303937 (to IN); 134950 (to HK); 253270 (to HK)), P{\"a}ivikki and Sakari Sohlberg Foundation (to IN), US National Institute of Health (NIH) award R01-GM114365 (to QF), Jane and Aatos Erkko Foundation (to HK and LK), Signe and Ane Gyllenberg Foundation (to HK and LK), State Research Grant (EVO) (to HK, LK and JJT), Hospital District of Southwest Finland State Research Grants (to JJT), Signe and Ane Gyllenberg Foundation (to JJT), Alfred Kordelin Foundation (to JJT), Sigrid Juselius Foundation (to JJT), Juho Vainio Foundation (to JJT), Finnish Medical Foundation (to JJT), and Emil Aaltonen Foundation (to JJT). Publisher Copyright: {\textcopyright} 2023 SPIE.; Optical Tomography and Spectroscopy of Tissue ; Conference date: 30-01-2023 Through 01-02-2023",

year = "2023",

doi = "10.1117/12.2649042",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

pages = "1--12",

editor = "Sergio Fantini and Paola Taroni",

booktitle = "Optical Tomography and Spectroscopy of Tissue XV",

address = "United States",

}

Hirvi, P, Nissilä, I, Maria, A, Fang, Q, Kotilahti, K, Heiskala, J, Tuulari, JJ, Karlsson, L, Hannukainen, A, Karlsson, H & Hyvönen, N 2023, Improved utilization of frequency-domain data for optical tomographic imaging of the human brain. in S Fantini & P Taroni (eds), Optical Tomography and Spectroscopy of Tissue XV., 123760A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12376, SPIE, pp. 1-12, Optical Tomography and Spectroscopy of Tissue, San Francisco, California, United States, 30/01/2023. https://doi.org/10.1117/12.2649042

Improved utilization of frequency-domain data for optical tomographic imaging of the human brain. / Hirvi, Pauliina; Nissilä, Ilkka; Maria, Ambika et al.
Optical Tomography and Spectroscopy of Tissue XV. ed. / Sergio Fantini; Paola Taroni. SPIE, 2023. p. 1-12 123760A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12376).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Improved utilization of frequency-domain data for optical tomographic imaging of the human brain

AU - Hirvi, Pauliina

AU - Nissilä, Ilkka

AU - Maria, Ambika

AU - Fang, Qianqian

AU - Kotilahti, Kalle

AU - Heiskala, Juha

AU - Tuulari, Jetro J.

AU - Karlsson, Linnea

AU - Hannukainen, Antti

AU - Karlsson, Hasse

AU - Hyvönen, Nuutti

N1 - Conference code: 15

PY - 2023

Y1 - 2023

N2 - Frequency-domain (FD) optical tomography instruments modulate the intensity of the light source at a radio frequency and measure the amplitude and phase shift of the detected photon density wave. The differing spatial sensitivities of amplitude and phase to the optical properties of tissue suggest that inclusion of phase data can improve the image reconstruction accuracy. This study describes our methodology for improved use of FD data in conjunction with a Monte Carlo (MC) forward solver (Monte Carlo eXtreme; MCX) and a voxel-based model of a two-year-old child’s head. The child participated our previous study where subjects were stimulated with affective (slow brushing) and non-affective touch (fast brushing) to their right forearm, and the responses were measured from the left hemisphere with our in-house 16-channel high-density FD system. We implemented the computation of the FD sensitivity profiles to the MCX photon simulation software, and validated the output against our in-house MC code. We used simulated and the real experimental touch response data to observe the effects of including both FD data types to the image reconstruction instead of amplitude data alone. For the simulated and experimental case, we observed that the inclusion of phase data increases the reconstructed contrast in the brain. The individual touch responses showed similarity to the group-level results in our original publication with 16 subjects and amplitude data alone, and other literature.

AB - Frequency-domain (FD) optical tomography instruments modulate the intensity of the light source at a radio frequency and measure the amplitude and phase shift of the detected photon density wave. The differing spatial sensitivities of amplitude and phase to the optical properties of tissue suggest that inclusion of phase data can improve the image reconstruction accuracy. This study describes our methodology for improved use of FD data in conjunction with a Monte Carlo (MC) forward solver (Monte Carlo eXtreme; MCX) and a voxel-based model of a two-year-old child’s head. The child participated our previous study where subjects were stimulated with affective (slow brushing) and non-affective touch (fast brushing) to their right forearm, and the responses were measured from the left hemisphere with our in-house 16-channel high-density FD system. We implemented the computation of the FD sensitivity profiles to the MCX photon simulation software, and validated the output against our in-house MC code. We used simulated and the real experimental touch response data to observe the effects of including both FD data types to the image reconstruction instead of amplitude data alone. For the simulated and experimental case, we observed that the inclusion of phase data increases the reconstructed contrast in the brain. The individual touch responses showed similarity to the group-level results in our original publication with 16 subjects and amplitude data alone, and other literature.

KW - Affective touch

KW - Atlas model

KW - Diffuse optical tomography

KW - Frequency-domain

KW - Image reconstruction

KW - Monte Carlo

KW - Regularization

KW - Toddler brain

UR - http://www.scopus.com/inward/record.url?scp=85159714509&partnerID=8YFLogxK

U2 - 10.1117/12.2649042

DO - 10.1117/12.2649042

M3 - Conference article in proceedings

AN - SCOPUS:85159714509

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

SP - 1

EP - 12

BT - Optical Tomography and Spectroscopy of Tissue XV

A2 - Fantini, Sergio

A2 - Taroni, Paola

PB - SPIE

T2 - Optical Tomography and Spectroscopy of Tissue

Y2 - 30 January 2023 through 1 February 2023

ER -

Hirvi P, Nissilä I, Maria A, Fang Q, Kotilahti K, Heiskala J et al. Improved utilization of frequency-domain data for optical tomographic imaging of the human brain. In Fantini S, Taroni P, editors, Optical Tomography and Spectroscopy of Tissue XV. SPIE. 2023. p. 1-12. 123760A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2649042

Improved utilization of frequency-domain data for optical tomographic imaging of the human brain

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

-: Centre of Excellence of Inverse Modelling and Imaging

-: Centre of Excellence of Inverse Modelling and Imaging

Multimodal neuroimaging of children

Science-IT

Cite this

Improved utilization of frequency-domain data for optical tomographic imaging of the human brain

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

Projects

-: Centre of Excellence of Inverse Modelling and Imaging

-: Centre of Excellence of Inverse Modelling and Imaging

Multimodal neuroimaging of children

Equipment

Science-IT

Cite this