IMPROVED GLYCOSYLATION OF PROTEINS IN HOST CELLS

Markus Aebi (Inventor), Farnoush Parsaie Nasab (Inventor), Alexander Frey (Inventor)

Research output: Patent

Abstract

The invention provides means and methods for an improved production of glycosylated recombinant proteins in lower eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in yeast. The invention provides genetically modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these modified cells.

Original languageEnglish
Patent numberWO2011134643
IPCC12P 21/ 02 A I
Priority date27/04/2010
Publication statusAccepted/In press - 3 Nov 2011
MoE publication typeH1 Granted patent

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