Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila; Reetta Vanhanen; Dawit A. Yohannes; Paivi Saavalainen; Seppo Meri; T. Sakari Jokiranta; Hanna Jarva; Ilkka P. Mattila; David Hamm; Silja Sormunen; Jari Saramaki; T. Petteri Arstila

doi:10.1002/eji.201948404

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila^*
, Reetta Vanhanen
, Dawit A. Yohannes
, Paivi Saavalainen
, Seppo Meri
, T. Sakari Jokiranta
, Hanna Jarva
, Ilkka P. Mattila
, David Hamm
, Silja Sormunen
, Jari Saramaki
, T. Petteri Arstila

^*Corresponding author for this work

University of Helsinki
Adaptive Biotechnologies

Research output: Contribution to journal › Letter › Scientific

8 Citations (Scopus)

Abstract

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

Original language	English
Pages (from-to)	748-751
Number of pages	4
Journal	European Journal of Immunology
Volume	50
Issue number	5
Early online date	14 Jan 2020
DOIs	https://doi.org/10.1002/eji.201948404
Publication status	Published - 1 May 2020
MoE publication type	B1 Non-refereed journal articles

Funding

We thank Tamas Bazsinka from University of Helsinki for expert technical assistance, and the families who participated in the study. The study has been funded by the University of Helsinki Research Foundation, Emil Aaltonen Foundation, Biomedicum Helsinki Foundation and M.D. Ph.D. program of the University of Helsinki

Keywords

CDR3
genetics
TCR repertoire
thymic selection
twins
DIVERSITY

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10.1002/eji.201948404

http://hdl.handle.net/10138/323639

Cite this

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title = "Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins",

abstract = "We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.",

keywords = "CDR3, genetics, TCR repertoire, thymic selection, twins, DIVERSITY",

author = "Nelli Heikkila and Reetta Vanhanen and Yohannes, \{Dawit A.\} and Paivi Saavalainen and Seppo Meri and Jokiranta, \{T. Sakari\} and Hanna Jarva and Mattila, \{Ilkka P.\} and David Hamm and Silja Sormunen and Jari Saramaki and Arstila, \{T. Petteri\}",

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month = may,

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doi = "10.1002/eji.201948404",

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T1 - Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

AU - Heikkila, Nelli

AU - Vanhanen, Reetta

AU - Yohannes, Dawit A.

AU - Saavalainen, Paivi

AU - Meri, Seppo

AU - Jokiranta, T. Sakari

AU - Jarva, Hanna

AU - Mattila, Ilkka P.

AU - Hamm, David

AU - Sormunen, Silja

AU - Saramaki, Jari

AU - Arstila, T. Petteri

PY - 2020/5/1

Y1 - 2020/5/1

N2 - We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

AB - We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

KW - CDR3

KW - genetics

KW - TCR repertoire

KW - thymic selection

KW - twins

KW - DIVERSITY

UR - https://www.scopus.com/pages/publications/85078028365

U2 - 10.1002/eji.201948404

DO - 10.1002/eji.201948404

M3 - Letter

C2 - 31872865

SN - 0014-2980

VL - 50

SP - 748

EP - 751

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 5

ER -

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

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Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Abstract

Funding

Keywords

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Science-IT

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