Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila*, Reetta Vanhanen, Dawit A. Yohannes, Paivi Saavalainen, Seppo Meri, T. Sakari Jokiranta, Hanna Jarva, Ilkka P. Mattila, David Hamm, Silja Sormunen, Jari Saramaki, T. Petteri Arstila

*Corresponding author for this work

Research output: Contribution to journalLetterScientific

3 Citations (Scopus)

Abstract

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

Original languageEnglish
Pages (from-to)748-751
Number of pages4
JournalEUROPEAN JOURNAL OF IMMUNOLOGY
Volume50
Issue number5
Early online date14 Jan 2020
DOIs
Publication statusPublished - 1 May 2020
MoE publication typeB1 Article in a scientific magazine

Keywords

  • CDR3
  • genetics
  • TCR repertoire
  • thymic selection
  • twins
  • DIVERSITY

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