Abstract
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
Original language | English |
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Pages (from-to) | 748-751 |
Number of pages | 4 |
Journal | European Journal of Immunology |
Volume | 50 |
Issue number | 5 |
Early online date | 14 Jan 2020 |
DOIs | |
Publication status | Published - 1 May 2020 |
MoE publication type | B1 Non-refereed journal articles |
Keywords
- CDR3
- genetics
- TCR repertoire
- thymic selection
- twins
- DIVERSITY