Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila*, Reetta Vanhanen, Dawit A. Yohannes, Paivi Saavalainen, Seppo Meri, T. Sakari Jokiranta, Hanna Jarva, Ilkka P. Mattila, David Hamm, Silja Sormunen, Jari Saramaki, T. Petteri Arstila

*Corresponding author for this work

Research output: Contribution to journalLetterScientificpeer-review

Abstract

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

Original languageEnglish
Pages (from-to)748-751
Number of pages4
JournalEUROPEAN JOURNAL OF IMMUNOLOGY
DOIs
Publication statusE-pub ahead of print - 14 Jan 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • CDR3
  • genetics
  • TCR repertoire
  • thymic selection
  • twins
  • DIVERSITY

Cite this

Heikkila, N., Vanhanen, R., Yohannes, D. A., Saavalainen, P., Meri, S., Jokiranta, T. S., ... Arstila, T. P. (2020). Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins. EUROPEAN JOURNAL OF IMMUNOLOGY, 748-751. https://doi.org/10.1002/eji.201948404