Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity

Sanja Asikainen, Kaarlo Paakinaho, Anna Kaisa Kyhkynen, Markus Hannula, Minna Malin, Niina Ahola, Minna Kellomäki, Jukka Seppälä*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

The ability to release active agents from a porous scaffold structure in situ enables the simultaneous structural support for the cells proliferating and differentiating towards tissue as well as the stimulation of tissue regeneration. Due to the great potentiality of such approach, drug-releasing scaffolds were fabricated from hydrolytically degradable polymers. Three copolymers of poly(ethylene glycol), ɛ-caprolactone, L- and D,L-lactide were synthesized and blended with bone-growth inducing active agents, dexamethasone (DM) and 2-phospho-L-ascorbic acid trisodium salt (AS). Porous scaffolds were prepared by means of super-critical carbon dioxide foaming. In the final scaffold structures, the particle size, location and the water solubility of the drug affected the release kinetics. As the large and water soluble AS particles were more exposed to the buffer solution compared to small DM particles, the AS release was burst-like whereas DM showed a long-term release. The material structure had a significant effect on the release kinetics as the porous scaffolds released active agents faster compared to the solid cylinders. Furthermore, this study showed the strong effect of polymer degradation and wettability on the release, which were more determinative than the pore architecture.

Original languageEnglish
Pages (from-to)165-175
Number of pages11
JournalEuropean Polymer Journal
Volume113
DOIs
Publication statusPublished - 1 Apr 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • 2-Phospho-L-ascorbic acid trisodium salt
  • Bulk degradation
  • Dexamethasone
  • Drug release
  • Hydrolytic degradation
  • Supercritical carbon dioxide foaming

Fingerprint Dive into the research topics of 'Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity'. Together they form a unique fingerprint.

  • Equipment

  • Cite this