Human ROBO1 regulates interaural interaction in auditory pathways

Satu Lamminmäki, Satu Massinen, Jaana Nopola-Hemmi, Juha Kere, Riitta Hari

Research output: Contribution to journalArticleScientificpeer-review

37 Citations (Scopus)
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Abstract

In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.
Original languageEnglish
Pages (from-to)966-971
JournalJOURNAL OF NEUROSCIENCE
Volume32
Issue number3
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Keywords

  • auditory pathways
  • interaural interaction
  • ROBO1

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