Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Ari M.P. Koskinen, Martin Brunner, Thomas Straub, Pauli Saarenketo, Kari Rissanen

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    Abstract

    Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine-3,4-dicarboxylate (1a/b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.
    Original languageEnglish
    Pages (from-to)268-270
    Number of pages3
    JournalLetters in Organic Chemistry
    Volume1
    Issue number3
    Publication statusPublished - 2004
    MoE publication typeA1 Journal article-refereed

    Keywords

    • alkylation
    • amino acids
    • diastereoselectivity

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  • Cite this

    Koskinen, A. M. P., Brunner, M., Straub, T., Saarenketo, P., & Rissanen, K. (2004). Highly Diastereoselective Methylation of Five-Ring N,O-Acetals. Letters in Organic Chemistry, 1(3), 268-270.