Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones

Andrejs Pelss; Esa T.T. Kumpulainen; Ari M.P. Koskinen

doi:10.1021/jo9017588

Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones

Andrejs Pelss, Esa T.T. Kumpulainen, Ari M.P. Koskinen

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Abstract

Highly chemoselective conjugate reduction of chiral R,β-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.

Original language	English
Pages (from-to)	7598-7601
Journal	Journal of organic chemistry
Volume	74
Issue number	19
DOIs	https://doi.org/10.1021/jo9017588
Publication status	Published - 2009
MoE publication type	A1 Journal article-refereed

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Copper Catalyzed Conjugate ReductionAccepted author manuscript, 235 KB

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title = "Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones",

abstract = "Highly chemoselective conjugate reduction of chiral R,β-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.",

author = "Andrejs Pelss and Kumpulainen, {Esa T.T.} and Koskinen, {Ari M.P.}",

year = "2009",

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T1 - Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones

AU - Pelss, Andrejs

AU - Kumpulainen, Esa T.T.

AU - Koskinen, Ari M.P.

PY - 2009

Y1 - 2009

N2 - Highly chemoselective conjugate reduction of chiral R,β-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.

AB - Highly chemoselective conjugate reduction of chiral R,β-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.

U2 - 10.1021/jo9017588

DO - 10.1021/jo9017588

M3 - Article

VL - 74

SP - 7598

EP - 7601

JO - Journal of organic chemistry

JF - Journal of organic chemistry

SN - 0022-3263

IS - 19

ER -

Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile alpha,beta-Unsaturated Amino Ketones

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