High angular resolution diffusion-weighted imaging in mild traumatic brain injury

Mehrbod Mohammadian*, Timo Roine, Jussi Hirvonen, Timo Kurki, Henna Ala-Seppälä, Janek Frantzén, Ari Katila, Anna Kyllönen, Henna Riikka Maanpää, Jussi Posti, Riikka Takala, Jussi Tallus, Olli Tenovuo

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)


We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury.

Original languageEnglish
Pages (from-to)174-180
Number of pages7
JournalNeuroImage: Clinical
Publication statusPublished - 1 Jan 2017
MoE publication typeA1 Journal article-refereed


  • Diffusion-weighted magnetic resonance imaging
  • Global approach
  • Magnetic resonance imaging
  • Probabilistic tractography
  • Traumatic brain injury


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