High-affinity multivalent DNA binding by using low-molecular-weight dendrons

Mauri A. Kostiainen*, John G. Hardy, David K. Smith

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

105 Citations (Scopus)


(Chemical Equation Presented) Nine spermines are better than one: Compound C2 exhibits high-affinity, salt-independent DNA binding as a consequence of the spermine array on its surface. Comparison with smaller dendrons and model compounds indicates a clear multivalency effect on binding.

Original languageEnglish
Pages (from-to)2556-2559
Number of pages4
JournalAngewandte Chemie
Issue number17
Publication statusPublished - 22 Apr 2005
MoE publication typeA1 Journal article-refereed


  • Dendrimers
  • DNA
  • Multivalency
  • Nanochemistry
  • Self-assembly


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