Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

Elina Nagaeva, Ivan Zubarev, Carolina Bengtsson Gonzales, Mikko Forss, Kasra Nikouei, Elena de Miguel, Lauri Elsilä, Anni Maija Linden, Jens Hjerling-Leffler, George J. Augustine, Esa R. Korpi

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)
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The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin (Sst)-expressing neurons in the mouse VTA. These neurons differ in their electrophysiological and morphological properties, anatomical localization, as well as mRNA expression profiles. Importantly, similar to cortical Sst-containing interneurons, most VTA Sst neurons express GABAergic inhibitory markers, but some of them also express glutamatergic excitatory markers and a subpopulation even express dopaminergic markers. Furthermore, only some of the proposed marker genes for cortical Sst neurons were expressed in the VTA Sst neurons. Physiologically, one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons. Overall, our results demonstrate the remarkable complexity and heterogeneity of VTA Sst neurons and suggest that these cells are multifunctional players in the midbrain reward circuitry.

Original languageEnglish
Article numbere59328
Pages (from-to)1-29
Number of pages29
Publication statusPublished - 4 Aug 2020
MoE publication typeA1 Journal article-refereed


  • dopamine
  • GABA
  • glutamate
  • midbrain
  • mouse
  • neuron subtypes
  • neuroscience
  • reward


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