Graph Theoretical Analysis of Cortical Networks based on Conscious Experience

Minji Lee, Benjamin Baird, Olivia Gosseries, Jaakko O. Nieminen, Melanie Boly, Giulio Tononi, Seong Whan Lee*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

1 Citation (Scopus)

Abstract

The aim of the study was to investigate differences in cortical networks based on the state of consciousness. Five subjects performed a serial-awakening paradigm with electroencephalography (EEG) recordings. We considered four states of consciousness: (1) non-rapid eye movement (NREM) sleep with no conscious experience, (2) NREM sleep with conscious experience, (3) rapid eye movement (REM) sleep with conscious experience, and (4) wakefulness. We applied graph theoretical analysis to explore the cortical connectivity and network properties in five frequency bands. Connectivity between EEG channels was evaluated with the weighted phase lag index (wPLI). The characteristic path length, transitivity, and clustering coefficient were computed to evaluate functional integration and segregation of the associated brain network. There were no significant differences in wPLI among the four states of consciousness. In the beta band, functional integration in wakefulness was higher than in NREM sleep. Regarding functional segregation, in the theta band, transitivity and clustering coefficient in NREM sleep with no conscious experience were stronger than in wakefulness or REM sleep, but clustering in the beta band showed an opposite effect. The observed differences may be related to cortical bistability and add to previously observed neural correlates of consciousness.

Original languageEnglish
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherIEEE
Pages3373-3376
Number of pages4
ISBN (Electronic)9781538613115
DOIs
Publication statusPublished - 1 Jul 2019
MoE publication typeA4 Article in a conference publication
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Society - Berlin, Germany
Duration: 23 Jul 201927 Jul 2019
Conference number: 41

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC
CountryGermany
CityBerlin
Period23/07/201927/07/2019

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  • Cite this

    Lee, M., Baird, B., Gosseries, O., Nieminen, J. O., Boly, M., Tononi, G., & Lee, S. W. (2019). Graph Theoretical Analysis of Cortical Networks based on Conscious Experience. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 3373-3376). [8857648] IEEE. https://doi.org/10.1109/EMBC.2019.8857648