Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

Jing-wen Lin; Chao Tang; Han-cheng Wei; Baowen Du; Chuan Chen; Minjin Wang; Yongzhao Zhou; Ming-xia Yu; Lu Cheng; Suvi Kuivanen; Natacha S. Ogando; Lev Levanov; Yuancun Zhao; Chang-ling Li; Ran Zhou; Zhidan Li; Yiming Zhang; Ke Sun; Chengdi Wang; Li Chen; Xia Xiao; Xiuran Zheng; Sha-sha Chen; Ruirui Yang; Dan Zhang; Mengying Xu; Junwei Song; Danrui Wang; Yupeng Li; ShiKun Lei; Wanqin Zeng; Qingxin Yang; Ping He; Yaoyao Zhang; Lifang Zhou; Ling Cao; Feng Luo; Huayi Liu; Liping Wang; Fei Ye; Ming Zhang; Mengjiao Li; Xinqiong Li; Kaiju Li; Bowen Ke; Jiannan Xu; Huiping Yang; Shusen He; Ming Pan; Yichen Yan; Yi Zha; Lingyu Jiang; Changxiu Yu; Yingfen Liu; Zhiyong Xu; Qingfeng Li; Yongmei Jiang; Jiufeng Sun; Wei Hong; Hongping Wei; Guangwen Lu; Olli Vapalahti; Yunzi Luo; Yuquan Wei; Thomas Connor; Wenjie Tan; Eric J. Snijder; Teemu Smura; Weimin Li; Jia Geng; Binwu Ying; Lu Chen

doi:10.1016/j.chom.2021.01.015

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

Jing-wen Lin, Chao Tang, Han-cheng Wei, Baowen Du, Chuan Chen, Minjin Wang, Yongzhao Zhou, Ming-xia Yu, Lu Cheng, Suvi Kuivanen, Natacha S. Ogando, Lev Levanov, Yuancun Zhao, Chang-ling Li, Ran Zhou, Zhidan Li, Yiming Zhang, Ke Sun, Chengdi Wang, Li ChenXia Xiao, Xiuran Zheng, Sha-sha Chen, Ruirui Yang, Dan Zhang, Mengying Xu, Junwei Song, Danrui Wang, Yupeng Li, ShiKun Lei, Wanqin Zeng, Qingxin Yang, Ping He, Yaoyao Zhang, Lifang Zhou, Ling Cao, Feng Luo, Huayi Liu, Liping Wang, Fei Ye, Ming Zhang, Mengjiao Li, Xinqiong Li, Kaiju Li, Bowen Ke, Jiannan Xu, Huiping Yang, Shusen He, Ming Pan, Yichen Yan, Yi Zha, Lingyu Jiang, Changxiu Yu, Yingfen Liu, Zhiyong Xu, Qingfeng Li, Yongmei Jiang, Jiufeng Sun, Wei Hong, Hongping Wei, Guangwen Lu, Olli Vapalahti, Yunzi Luo, Yuquan Wei, Thomas Connor, Wenjie Tan, Eric J. Snijder, Teemu Smura, Weimin Li, Jia Geng, Binwu Ying, Lu Chen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Number of pages	41
Journal	CELL HOST AND MICROBE
DOIs	https://doi.org/10.1016/j.chom.2021.01.015
Publication status	E-pub ahead of print - 29 Jan 2021
MoE publication type	A1 Journal article-refereed

Keywords

SARS-CoV-2
COVID-19

Access to Document

10.1016/j.chom.2021.01.015

Embargoed Document

Lin_Genomic.1-s2.0-S1931312821000457-main
Accepted author manuscript, 29.2 MB
Licence: CC BY-NC-ND
Embargo ends: 29/01/2022

1 Active

Systematic approach to study alternative splicing from scRNA-seq in cancer
Cheng, L.
01/09/2020 → 31/08/2023
Project: Academy of Finland: Other research funding

Cite this

Lin, J., Tang, C., Wei, H., Du, B., Chen, C., Wang, M., Zhou, Y., Yu, M., Cheng, L., Kuivanen, S., Ogando, N. S., Levanov, L., Zhao, Y., Li, C., Zhou, R., Li, Z., Zhang, Y., Sun, K., Wang, C., ... Chen, L. (2021). Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. CELL HOST AND MICROBE. https://doi.org/10.1016/j.chom.2021.01.015

Lin, Jing-wen ; Tang, Chao ; Wei, Han-cheng ; Du, Baowen ; Chen, Chuan ; Wang, Minjin ; Zhou, Yongzhao ; Yu, Ming-xia ; Cheng, Lu ; Kuivanen, Suvi ; Ogando, Natacha S. ; Levanov, Lev ; Zhao, Yuancun ; Li, Chang-ling ; Zhou, Ran ; Li, Zhidan ; Zhang, Yiming ; Sun, Ke ; Wang, Chengdi ; Chen, Li ; Xiao, Xia ; Zheng, Xiuran ; Chen, Sha-sha ; Yang, Ruirui ; Zhang, Dan ; Xu, Mengying ; Song, Junwei ; Wang, Danrui ; Li, Yupeng ; Lei, ShiKun ; Zeng, Wanqin ; Yang, Qingxin ; He, Ping ; Zhang, Yaoyao ; Zhou, Lifang ; Cao, Ling ; Luo, Feng ; Liu, Huayi ; Wang, Liping ; Ye, Fei ; Zhang, Ming ; Li, Mengjiao ; Li, Xinqiong ; Li, Kaiju ; Ke, Bowen ; Xu, Jiannan ; Yang, Huiping ; He, Shusen ; Pan, Ming ; Yan, Yichen ; Zha, Yi ; Jiang, Lingyu ; Yu, Changxiu ; Liu, Yingfen ; Xu, Zhiyong ; Li, Qingfeng ; Jiang, Yongmei ; Sun, Jiufeng ; Hong, Wei ; Wei, Hongping ; Lu, Guangwen ; Vapalahti, Olli ; Luo, Yunzi ; Wei, Yuquan ; Connor, Thomas ; Tan, Wenjie ; Snijder, Eric J. ; Smura, Teemu ; Li, Weimin ; Geng, Jia ; Ying, Binwu ; Chen, Lu. / Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. In: CELL HOST AND MICROBE. 2021.

@article{a799c7c6b71b4abfa71e87b1f917e10e,

title = "Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response",

keywords = "SARS-CoV-2, COVID-19",

author = "Jing-wen Lin and Chao Tang and Han-cheng Wei and Baowen Du and Chuan Chen and Minjin Wang and Yongzhao Zhou and Ming-xia Yu and Lu Cheng and Suvi Kuivanen and Ogando, {Natacha S.} and Lev Levanov and Yuancun Zhao and Chang-ling Li and Ran Zhou and Zhidan Li and Yiming Zhang and Ke Sun and Chengdi Wang and Li Chen and Xia Xiao and Xiuran Zheng and Sha-sha Chen and Ruirui Yang and Dan Zhang and Mengying Xu and Junwei Song and Danrui Wang and Yupeng Li and ShiKun Lei and Wanqin Zeng and Qingxin Yang and Ping He and Yaoyao Zhang and Lifang Zhou and Ling Cao and Feng Luo and Huayi Liu and Liping Wang and Fei Ye and Ming Zhang and Mengjiao Li and Xinqiong Li and Kaiju Li and Bowen Ke and Jiannan Xu and Huiping Yang and Shusen He and Ming Pan and Yichen Yan and Yi Zha and Lingyu Jiang and Changxiu Yu and Yingfen Liu and Zhiyong Xu and Qingfeng Li and Yongmei Jiang and Jiufeng Sun and Wei Hong and Hongping Wei and Guangwen Lu and Olli Vapalahti and Yunzi Luo and Yuquan Wei and Thomas Connor and Wenjie Tan and Snijder, {Eric J.} and Teemu Smura and Weimin Li and Jia Geng and Binwu Ying and Lu Chen",

year = "2021",

month = jan,

day = "29",

doi = "10.1016/j.chom.2021.01.015",

language = "English",

journal = "CELL HOST AND MICROBE",

issn = "1931-3128",

publisher = "Cell Press",

}

Lin, J, Tang, C, Wei, H, Du, B, Chen, C, Wang, M, Zhou, Y, Yu, M, Cheng, L, Kuivanen, S, Ogando, NS, Levanov, L, Zhao, Y, Li, C, Zhou, R, Li, Z, Zhang, Y, Sun, K, Wang, C, Chen, L, Xiao, X, Zheng, X, Chen, S, Yang, R, Zhang, D, Xu, M, Song, J, Wang, D, Li, Y, Lei, S, Zeng, W, Yang, Q, He, P, Zhang, Y, Zhou, L, Cao, L, Luo, F, Liu, H, Wang, L, Ye, F, Zhang, M, Li, M, Li, X, Li, K, Ke, B, Xu, J, Yang, H, He, S, Pan, M, Yan, Y, Zha, Y, Jiang, L, Yu, C, Liu, Y, Xu, Z, Li, Q, Jiang, Y, Sun, J, Hong, W, Wei, H, Lu, G, Vapalahti, O, Luo, Y, Wei, Y, Connor, T, Tan, W, Snijder, EJ, Smura, T, Li, W, Geng, J, Ying, B & Chen, L 2021, 'Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response', CELL HOST AND MICROBE. https://doi.org/10.1016/j.chom.2021.01.015

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. / Lin, Jing-wen; Tang, Chao; Wei, Han-cheng; Du, Baowen; Chen, Chuan; Wang, Minjin; Zhou, Yongzhao; Yu, Ming-xia; Cheng, Lu; Kuivanen, Suvi; Ogando, Natacha S.; Levanov, Lev; Zhao, Yuancun; Li, Chang-ling; Zhou, Ran; Li, Zhidan; Zhang, Yiming; Sun, Ke; Wang, Chengdi; Chen, Li; Xiao, Xia; Zheng, Xiuran; Chen, Sha-sha; Yang, Ruirui; Zhang, Dan; Xu, Mengying; Song, Junwei; Wang, Danrui; Li, Yupeng; Lei, ShiKun; Zeng, Wanqin; Yang, Qingxin; He, Ping; Zhang, Yaoyao; Zhou, Lifang; Cao, Ling; Luo, Feng; Liu, Huayi; Wang, Liping; Ye, Fei; Zhang, Ming; Li, Mengjiao; Li, Xinqiong; Li, Kaiju; Ke, Bowen; Xu, Jiannan; Yang, Huiping; He, Shusen; Pan, Ming; Yan, Yichen; Zha, Yi; Jiang, Lingyu; Yu, Changxiu; Liu, Yingfen; Xu, Zhiyong; Li, Qingfeng; Jiang, Yongmei; Sun, Jiufeng; Hong, Wei; Wei, Hongping; Lu, Guangwen; Vapalahti, Olli; Luo, Yunzi; Wei, Yuquan; Connor, Thomas; Tan, Wenjie; Snijder, Eric J.; Smura, Teemu; Li, Weimin; Geng, Jia; Ying, Binwu; Chen, Lu.

In: CELL HOST AND MICROBE, 29.01.2021.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

AU - Lin, Jing-wen

AU - Tang, Chao

AU - Wei, Han-cheng

AU - Du, Baowen

AU - Chen, Chuan

AU - Wang, Minjin

AU - Zhou, Yongzhao

AU - Yu, Ming-xia

AU - Cheng, Lu

AU - Kuivanen, Suvi

AU - Ogando, Natacha S.

AU - Levanov, Lev

AU - Zhao, Yuancun

AU - Li, Chang-ling

AU - Zhou, Ran

AU - Li, Zhidan

AU - Zhang, Yiming

AU - Sun, Ke

AU - Wang, Chengdi

AU - Chen, Li

AU - Xiao, Xia

AU - Zheng, Xiuran

AU - Chen, Sha-sha

AU - Yang, Ruirui

AU - Zhang, Dan

AU - Xu, Mengying

AU - Song, Junwei

AU - Wang, Danrui

AU - Li, Yupeng

AU - Lei, ShiKun

AU - Zeng, Wanqin

AU - Yang, Qingxin

AU - He, Ping

AU - Zhang, Yaoyao

AU - Zhou, Lifang

AU - Cao, Ling

AU - Luo, Feng

AU - Liu, Huayi

AU - Wang, Liping

AU - Ye, Fei

AU - Zhang, Ming

AU - Li, Mengjiao

AU - Li, Xinqiong

AU - Li, Kaiju

AU - Ke, Bowen

AU - Xu, Jiannan

AU - Yang, Huiping

AU - He, Shusen

AU - Pan, Ming

AU - Yan, Yichen

AU - Zha, Yi

AU - Jiang, Lingyu

AU - Yu, Changxiu

AU - Liu, Yingfen

AU - Xu, Zhiyong

AU - Li, Qingfeng

AU - Jiang, Yongmei

AU - Sun, Jiufeng

AU - Hong, Wei

AU - Wei, Hongping

AU - Lu, Guangwen

AU - Vapalahti, Olli

AU - Luo, Yunzi

AU - Wei, Yuquan

AU - Connor, Thomas

AU - Tan, Wenjie

AU - Snijder, Eric J.

AU - Smura, Teemu

AU - Li, Weimin

AU - Geng, Jia

AU - Ying, Binwu

AU - Chen, Lu

PY - 2021/1/29

Y1 - 2021/1/29

KW - SARS-CoV-2

KW - COVID-19

U2 - 10.1016/j.chom.2021.01.015

DO - 10.1016/j.chom.2021.01.015

M3 - Article

JO - CELL HOST AND MICROBE

JF - CELL HOST AND MICROBE

SN - 1931-3128

ER -

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

Keywords

Access to Document

Embargoed Document

Systematic approach to study alternative splicing from scRNA-seq in cancer

Cite this