Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Jaana Simola; Felix Siebenhühner; Vladislav Myrov; Katri Kantojärvi; Tiina Paunio; J. Matias Palva; Elvira Brattico; Satu Palva

doi:10.1016/j.isci.2022.104985

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Jaana Simola^*, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva

^*Corresponding author for this work

Department of Neuroscience and Biomedical Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val¹⁵⁸Met and brain-derived neurotrophic factor (BDNF) Val⁶⁶Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

Original language	English
Article number	104985
Pages (from-to)	1-21
Number of pages	21
Journal	iScience
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2022.104985
Publication status	Published - 16 Sept 2022
MoE publication type	A1 Journal article-refereed

Keywords

Biological sciences
Cognitive neuroscience
Neuroscience

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10.1016/j.isci.2022.104985

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillationsFinal published version, 3.42 MBLicence: CC BY-NC-ND

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title = "Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations",

abstract = "Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.",

keywords = "Biological sciences, Cognitive neuroscience, Neuroscience",

author = "Jaana Simola and Felix Siebenh{\"u}hner and Vladislav Myrov and Katri Kantoj{\"a}rvi and Tiina Paunio and Palva, {J. Matias} and Elvira Brattico and Satu Palva",

note = "Funding Information: This work was supported by the Jane and Aatos Erkko Foundation , by the Academy of Finland ( SA 1266402 , 1267030 to S.P., SA 1266745 , 1296304 to J.M.P., and SA 1294761 to J.S.). Publisher Copyright: {\textcopyright} 2022 The Authors",

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doi = "10.1016/j.isci.2022.104985",

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T1 - Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

AU - Simola, Jaana

AU - Siebenhühner, Felix

AU - Myrov, Vladislav

AU - Kantojärvi, Katri

AU - Paunio, Tiina

AU - Palva, J. Matias

AU - Brattico, Elvira

AU - Palva, Satu

N1 - Funding Information: This work was supported by the Jane and Aatos Erkko Foundation , by the Academy of Finland ( SA 1266402 , 1267030 to S.P., SA 1266745 , 1296304 to J.M.P., and SA 1294761 to J.S.). Publisher Copyright: © 2022 The Authors

PY - 2022/9/16

Y1 - 2022/9/16

N2 - Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

AB - Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

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Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

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