Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Jaana Simola*, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

Original languageEnglish
Article number104985
Pages (from-to)1-21
Number of pages21
JournaliScience
Volume25
Issue number9
DOIs
Publication statusPublished - 16 Sep 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • Biological sciences
  • Cognitive neuroscience
  • Neuroscience

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