Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes

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Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes. / Doni, Giovanni; Kostiainen, Mauri A.; Danani, Andrea; Pavan, Giovanni M.

In: Nano Letters, Vol. 11, No. 2, 2011, p. 723-728.

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Doni, Giovanni ; Kostiainen, Mauri A. ; Danani, Andrea ; Pavan, Giovanni M. / Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes. In: Nano Letters. 2011 ; Vol. 11, No. 2. pp. 723-728.

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@article{e31d412b5db2409292a0939897f63a22,
title = "Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes",
abstract = "In this work molecular dynamics simulation identifies a clear link between the dendron virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self assemblies, potentially enabling the control of the supra molecular properties by acting at the single-molecule level.",
keywords = "Molecular recognition, self-assembly, dendrons, molecular modeling, hierarchical complexes, intermolecular interactions, DENDRIMERS, DNA, MULTIVALENCY, CHEMISTRY, STRENGTH, ELECTROSTATICS, COOPERATIVITY, NANOPARTICLES, MICROBICIDE, PREVENTION",
author = "Giovanni Doni and Kostiainen, {Mauri A.} and Andrea Danani and Pavan, {Giovanni M.}",
year = "2011",
doi = "10.1021/nl103857e",
language = "English",
volume = "11",
pages = "723--728",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "AMERICAN CHEMICAL SOCIETY",
number = "2",

}

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TY - JOUR

T1 - Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes

AU - Doni, Giovanni

AU - Kostiainen, Mauri A.

AU - Danani, Andrea

AU - Pavan, Giovanni M.

PY - 2011

Y1 - 2011

N2 - In this work molecular dynamics simulation identifies a clear link between the dendron virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self assemblies, potentially enabling the control of the supra molecular properties by acting at the single-molecule level.

AB - In this work molecular dynamics simulation identifies a clear link between the dendron virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self assemblies, potentially enabling the control of the supra molecular properties by acting at the single-molecule level.

KW - Molecular recognition

KW - self-assembly

KW - dendrons

KW - molecular modeling

KW - hierarchical complexes

KW - intermolecular interactions

KW - DENDRIMERS

KW - DNA

KW - MULTIVALENCY

KW - CHEMISTRY

KW - STRENGTH

KW - ELECTROSTATICS

KW - COOPERATIVITY

KW - NANOPARTICLES

KW - MICROBICIDE

KW - PREVENTION

U2 - 10.1021/nl103857e

DO - 10.1021/nl103857e

M3 - Article

VL - 11

SP - 723

EP - 728

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 2

ER -

ID: 4721646