Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes

Research output: Contribution to journalArticleScientificpeer-review


Research units

  • Radboud University Nijmegen
  • University of Applied Sciences of Southern Switzerland
  • Università della Svizzera italiana


In this work molecular dynamics simulation identifies a clear link between the dendron virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self assemblies, potentially enabling the control of the supra molecular properties by acting at the single-molecule level.


Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalNano Letters
Issue number2
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

    Research areas

  • Molecular recognition, self-assembly, dendrons, molecular modeling, hierarchical complexes, intermolecular interactions, DENDRIMERS, DNA, MULTIVALENCY, CHEMISTRY, STRENGTH, ELECTROSTATICS, COOPERATIVITY, NANOPARTICLES, MICROBICIDE, PREVENTION

ID: 4721646