Generation-Dependent Molecular Recognition Controls Self-Assembly in Supramolecular Dendron-Virus Complexes

Giovanni Doni, Mauri A. Kostiainen, Andrea Danani, Giovanni M. Pavan*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

In this work molecular dynamics simulation identifies a clear link between the dendron virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self assemblies, potentially enabling the control of the supra molecular properties by acting at the single-molecule level.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalNano Letters
Volume11
Issue number2
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Keywords

  • Molecular recognition
  • self-assembly
  • dendrons
  • molecular modeling
  • hierarchical complexes
  • intermolecular interactions
  • DENDRIMERS
  • DNA
  • MULTIVALENCY
  • CHEMISTRY
  • STRENGTH
  • ELECTROSTATICS
  • COOPERATIVITY
  • NANOPARTICLES
  • MICROBICIDE
  • PREVENTION

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