Gene regulatory network inference from sparsely sampled noisy data

Atte Aalto, Lauri Viitasaari, Pauliina Ilmonen, Laurent Mombaerts, Jorge Gonçalves*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
60 Downloads (Pure)

Abstract

The complexity of biological systems is encoded in gene regulatory networks. Unravelling this intricate web is a fundamental step in understanding the mechanisms of life and eventually developing efficient therapies to treat and cure diseases. The major obstacle in inferring gene regulatory networks is the lack of data. While time series data are nowadays widely available, they are typically noisy, with low sampling frequency and overall small number of samples. This paper develops a method called BINGO to specifically deal with these issues. Benchmarked with both real and simulated time-series data covering many different gene regulatory networks, BINGO clearly and consistently outperforms state-of-the-art methods. The novelty of BINGO lies in a nonparametric approach featuring statistical sampling of continuous gene expression profiles. BINGO’s superior performance and ease of use, even by non-specialists, make gene regulatory network inference available to any researcher, helping to decipher the complex mechanisms of life.

Original languageEnglish
Article number3493
Number of pages9
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020
MoE publication typeA1 Journal article-refereed

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