Garner’s aldehyde as a versatile intermediate in the synthesis of enantiopure natural products

Mikko Passiniemi, Ari Koskinen

    Research output: Contribution to journalArticleScientificpeer-review

    39 Citations (Scopus)
    130 Downloads (Pure)

    Abstract

    Since its introduction to the synthetic community in 1984, Garner’s aldehyde has gained substantial attention as a chiral intermediate for the synthesis of numerous amino alcohol derivatives. This review presents some of the most successful carbon
    chain elongation reactions, namely carbonyl alkylations and olefinations. The literature is reviewed with particular attention on understanding how to avoid the deleterious epimerization of the existing stereocenter in Garner’s aldehyde.
    Original languageEnglish
    Pages (from-to)2641-2659
    JournalBEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
    Volume9
    DOIs
    Publication statusPublished - 2013
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Dive into the research topics of 'Garner’s aldehyde as a versatile intermediate in the synthesis of enantiopure natural products'. Together they form a unique fingerprint.

    Cite this