TY - JOUR
T1 - Fusion Dynamics of Hybrid Cell–Microparticle Aggregates
T2 - A Jelly Pearl Model
AU - Beaune, Grégory
AU - Sinkkonen, Laura
AU - Gonzalez-Rodriguez, David
AU - Timonen, Jaakko V.I.
AU - Brochard-Wyart, Françoise
N1 - Funding Information:
This work was supported by the Academy of Finland Center of Excellence Programme (2014–2019).
Publisher Copyright:
© 2022 American Chemical Society
PY - 2022/2/3
Y1 - 2022/2/3
N2 - We study the fusion of homogeneous cell aggregates and of hybrid aggregates combining cells and microparticles. In all cases, we find that the contact area does not vary linearly over time, as observed for liquid drops, but rather it follows a power law in t2/3. This result is interpreted by generalizing the fusion model of soft viscoelastic solid balls to viscoelastic liquid balls, akin to jelly pearls. We also explore the asymmetric fusion between a homogeneous aggregate and a hybrid aggregate. This latter experiment allows the determination of the self-diffusion coefficient of the cells in a tissue by following the spatial distribution of internalized particles in the cells.
AB - We study the fusion of homogeneous cell aggregates and of hybrid aggregates combining cells and microparticles. In all cases, we find that the contact area does not vary linearly over time, as observed for liquid drops, but rather it follows a power law in t2/3. This result is interpreted by generalizing the fusion model of soft viscoelastic solid balls to viscoelastic liquid balls, akin to jelly pearls. We also explore the asymmetric fusion between a homogeneous aggregate and a hybrid aggregate. This latter experiment allows the determination of the self-diffusion coefficient of the cells in a tissue by following the spatial distribution of internalized particles in the cells.
UR - http://www.scopus.com/inward/record.url?scp=85124476853&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.1c02949
DO - 10.1021/acs.langmuir.1c02949
M3 - Article
AN - SCOPUS:85124476853
SN - 0743-7463
VL - 38
SP - 5296
EP - 5306
JO - Langmuir
JF - Langmuir
IS - 17
ER -