Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Patrícia Figueiredo
  • Cláudio Ferro
  • Marianna Kemell
  • Zehua Liu
  • Alexandros Kiriazis
  • Kalle Lintinen
  • Helena F. Florindo
  • Jari Yli-Kauhaluoma
  • Jouni Hirvonen
  • Mauri A. Kostiainen
  • Hélder A. Santos

Research units

  • University of Helsinki
  • University of Lisbon

Abstract

Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

Details

Original languageEnglish
Pages (from-to)2581-2596
Number of pages16
JournalNanomedicine
Volume12
Issue number21
Publication statusPublished - 1 Nov 2017
MoE publication typeA1 Journal article-refereed

    Research areas

  • antiproliferative effect, benzazulene, carboxylated lignin nanoparticles, drug loading, pH-responsive release, targeting functionalization

ID: 16230288