Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Patrícia Figueiredo; Cláudio Ferro; Marianna Kemell; Zehua Liu; Alexandros Kiriazis; Kalle Lintinen; Helena F. Florindo; Jari Yli-Kauhaluoma; Jouni Hirvonen; Mauri A. Kostiainen; Hélder A. Santos

doi:10.2217/nnm-2017-0219

Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Patrícia Figueiredo^*, Cláudio Ferro, Marianna Kemell, Zehua Liu, Alexandros Kiriazis, Kalle Lintinen, Helena F. Florindo, Jari Yli-Kauhaluoma, Jouni Hirvonen, Mauri A. Kostiainen, Hélder A. Santos

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

107 Citations (Scopus)

Abstract

Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

Original language	English
Pages (from-to)	2581-2596
Number of pages	16
Journal	Nanomedicine
Volume	12
Issue number	21
DOIs	https://doi.org/10.2217/nnm-2017-0219
Publication status	Published - 1 Nov 2017
MoE publication type	A1 Journal article-refereed

Keywords

antiproliferative effect
benzazulene
carboxylated lignin nanoparticles
drug loading
pH-responsive release
targeting functionalization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2017-0219

Cite this

@article{00a06875e0c34ba3b2265dc1156287bc,

title = "Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs",

abstract = "Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials \& methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.",

keywords = "antiproliferative effect, benzazulene, carboxylated lignin nanoparticles, drug loading, pH-responsive release, targeting functionalization",

author = "Patr{\'i}cia Figueiredo and Cl{\'a}udio Ferro and Marianna Kemell and Zehua Liu and Alexandros Kiriazis and Kalle Lintinen and Florindo, \{Helena F.\} and Jari Yli-Kauhaluoma and Jouni Hirvonen and Kostiainen, \{Mauri A.\} and Santos, \{H{\'e}lder A.\}",

year = "2017",

month = nov,

day = "1",

doi = "10.2217/nnm-2017-0219",

language = "English",

volume = "12",

pages = "2581--2596",

journal = "Nanomedicine",

issn = "1743-5889",

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TY - JOUR

T1 - Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

AU - Figueiredo, Patrícia

AU - Ferro, Cláudio

AU - Kemell, Marianna

AU - Liu, Zehua

AU - Kiriazis, Alexandros

AU - Lintinen, Kalle

AU - Florindo, Helena F.

AU - Yli-Kauhaluoma, Jari

AU - Hirvonen, Jouni

AU - Kostiainen, Mauri A.

AU - Santos, Hélder A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

AB - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

KW - antiproliferative effect

KW - benzazulene

KW - carboxylated lignin nanoparticles

KW - drug loading

KW - pH-responsive release

KW - targeting functionalization

UR - https://www.scopus.com/pages/publications/85032441481

U2 - 10.2217/nnm-2017-0219

DO - 10.2217/nnm-2017-0219

M3 - Article

AN - SCOPUS:85032441481

SN - 1743-5889

VL - 12

SP - 2581

EP - 2596

JO - Nanomedicine

JF - Nanomedicine

IS - 21

ER -

Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Abstract

Keywords

UN SDGs

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Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Abstract

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UN SDGs

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