TY - JOUR
T1 - Functional network connectivity and topology during naturalistic stimulus is altered in first-episode psychosis
AU - Rikandi, Eva
AU - Mäntylä, Teemu
AU - Lindgren, Maija
AU - Kieseppä, Tuula
AU - Suvisaari, Jaana
AU - Raij, Tuukka T.
N1 - Funding Information:
This work was supported by the Sigrid Jusélius Foundation (J.S., E.R.), the Finnish Cultural Foundation (J.S. and T.M.), European Union Seventh Framework Programme ( FP7/2007–2013 ), grant agreement no 602478 (J.S.), the Jalmari and Rauha Ahokas Foundation (T.M.), the Doctoral Program Brain and Mind of the University of Helsinki (T.M.), the Yrjö Jahnsson Foundation (# 6781 to M.L.), the Päivikki and Sakari Sohlberg Foundation (M.L.), the Academy of Finland (# 278171 to J.S. and T.T.R.) and the Finnish Medical Foundation (T.T.R.)
Funding Information:
This work was supported by the Sigrid Jus?lius Foundation (J.S., E.R.), the Finnish Cultural Foundation (J.S. and T.M.), European Union Seventh Framework Programme (FP7/2007?2013), grant agreement no 602478 (J.S.), the Jalmari and Rauha Ahokas Foundation (T.M.), the Doctoral Program Brain and Mind of the University of Helsinki (T.M.), the Yrj? Jahnsson Foundation (#6781 to M.L.), the P?ivikki and Sakari Sohlberg Foundation (M.L.), the Academy of Finland (#278171 to J.S. and T.T.R.) and the Finnish Medical Foundation (T.T.R.)
Publisher Copyright:
© 2022 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - Background: Psychotic disorders have been suggested to derive from dysfunctional integration of signaling between brain regions. Earlier studies have found several changes in functional network synchronization as well as altered network topology in patients with psychotic disorders. However, studies have used mainly resting-state that makes it more difficult to link functional alterations to any specific stimulus or experience. We set out to examine functional connectivity as well as graph (topological) measures and their association to symptoms in first-episode psychosis patients during movie viewing. Our goal was to understand whole-brain functional dynamics of complex naturalistic information processing in psychosis and changes in brain functional organization related to symptoms. Methods: 71 first-episode psychosis patients and 57 control subjects watched scenes from the movie Alice in Wonderland during 3 T fMRI. We compared functional connectivity and graph measures indicating integration, segregation and centrality between groups, and examined the association between topology and symptom scores in the patient group. Results: We identified a subnetwork with predominantly decreased links of functional connectivity in first-episode psychosis patients. The subnetwork was mainly comprised of nodes of and links between the cingulo-opercular, sensorimotor and default-mode networks. In topological measures, we observed between-group differences in properties of centrality. Conclusions: Functional brain networks are affected during naturalistic information processing already in the early stages of psychosis, concentrated in salience- and cognitive control-related hubs and subnetworks. Understanding these aberrant dynamics could add to better targeted cognitive and behavioral interventions in the early stages of psychotic disorders.
AB - Background: Psychotic disorders have been suggested to derive from dysfunctional integration of signaling between brain regions. Earlier studies have found several changes in functional network synchronization as well as altered network topology in patients with psychotic disorders. However, studies have used mainly resting-state that makes it more difficult to link functional alterations to any specific stimulus or experience. We set out to examine functional connectivity as well as graph (topological) measures and their association to symptoms in first-episode psychosis patients during movie viewing. Our goal was to understand whole-brain functional dynamics of complex naturalistic information processing in psychosis and changes in brain functional organization related to symptoms. Methods: 71 first-episode psychosis patients and 57 control subjects watched scenes from the movie Alice in Wonderland during 3 T fMRI. We compared functional connectivity and graph measures indicating integration, segregation and centrality between groups, and examined the association between topology and symptom scores in the patient group. Results: We identified a subnetwork with predominantly decreased links of functional connectivity in first-episode psychosis patients. The subnetwork was mainly comprised of nodes of and links between the cingulo-opercular, sensorimotor and default-mode networks. In topological measures, we observed between-group differences in properties of centrality. Conclusions: Functional brain networks are affected during naturalistic information processing already in the early stages of psychosis, concentrated in salience- and cognitive control-related hubs and subnetworks. Understanding these aberrant dynamics could add to better targeted cognitive and behavioral interventions in the early stages of psychotic disorders.
KW - fMRI
KW - Functional connectivity
KW - Naturalistic stimulus
KW - Networks
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85123678990&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2022.01.006
DO - 10.1016/j.schres.2022.01.006
M3 - Article
C2 - 35092893
AN - SCOPUS:85123678990
SN - 0920-9964
VL - 241
SP - 83
EP - 91
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -
