Projects per year
Abstract
Objective
To assess the effects to functional connectivity (FC) caused by lesions related to spastic diplegic cerebral palsy (CP) in children and adolescents using multiple imaging modalities.
Methods
We used resting state magnetoencephalography (MEG) envelope signals in alpha, beta and gamma ranges and resting state functional magnetic resonance imaging (fMRI) signals to quantify FC between selected sensorimotor regions of interest (ROIs) in 11 adolescents with spastic diplegic cerebral palsy and 24 typically developing controls. Motor performance of the hands was quantified with gross motor, fine motor and kinesthesia tests.
Results
In fMRI, participants with CP showed enhanced FC within posterior parietal regions; in MEG, they showed enhanced interhemispheric FC between sensorimotor regions and posterior parietal regions both in alpha and lower beta bands. There was a correlation between the kinesthesia score and fronto-parietal connectivity in the control population.
Conclusions
CP is associated with enhanced FC in sensorimotor network. This difference is not correlated with hand coordination performance. The effect of the lesion is likely not fully captured by temporal correlation of ROI signals.
Significance
Brain lesions can show as increased temporal correlation of activity between remote brain areas. We suggest this effect is likely separate from typical physiological correlates of functional connectivity.
To assess the effects to functional connectivity (FC) caused by lesions related to spastic diplegic cerebral palsy (CP) in children and adolescents using multiple imaging modalities.
Methods
We used resting state magnetoencephalography (MEG) envelope signals in alpha, beta and gamma ranges and resting state functional magnetic resonance imaging (fMRI) signals to quantify FC between selected sensorimotor regions of interest (ROIs) in 11 adolescents with spastic diplegic cerebral palsy and 24 typically developing controls. Motor performance of the hands was quantified with gross motor, fine motor and kinesthesia tests.
Results
In fMRI, participants with CP showed enhanced FC within posterior parietal regions; in MEG, they showed enhanced interhemispheric FC between sensorimotor regions and posterior parietal regions both in alpha and lower beta bands. There was a correlation between the kinesthesia score and fronto-parietal connectivity in the control population.
Conclusions
CP is associated with enhanced FC in sensorimotor network. This difference is not correlated with hand coordination performance. The effect of the lesion is likely not fully captured by temporal correlation of ROI signals.
Significance
Brain lesions can show as increased temporal correlation of activity between remote brain areas. We suggest this effect is likely separate from typical physiological correlates of functional connectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 4-14 |
| Journal | Clinical Neurophysiology |
| Volume | 157 |
| Early online date | Nov 2023 |
| DOIs | |
| Publication status | Published - Jan 2024 |
| MoE publication type | A1 Journal article-refereed |
Fingerprint
Dive into the research topics of 'Functional connectivity of sensorimotor network is enhanced in spastic diplegic cerebral palsy : A multimodal study using fMRI and MEG'. Together they form a unique fingerprint.Projects
- 2 Finished
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Proprioception in sensorimotor integration in health and disease
Piitulainen, H. (Principal investigator)
01/09/2016 → 31/12/2018
Project: Academy of Finland: Other research funding
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Proprioception in sensorimotor integration in health and disease
Piitulainen, H. (Principal investigator), Nurmi, T. (Project Member), Aydogan, D. B. (Project Member) & Matilainen, N. (Project Member)
01/09/2016 → 31/08/2019
Project: Academy of Finland: Other research funding
Equipment
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Aalto Neuroimaging Infrastructure
Jousmäki, V. (Manager)
School of ScienceFacility/equipment: Facility
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