From jamming to collective cell migration through a boundary induced transition

Oleksandr Chepizhko, Maria Chiara Lionetti, Chiara Malinverno, Costanza Giampietro, Giorgio Scita, Stefano Zapperi*, Caterina A.M. La Porta

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

30 Citations (Scopus)

Abstract

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

Original languageEnglish
Pages (from-to)3774-3782
Number of pages9
JournalSoft Matter
Volume14
Issue number19
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA1 Journal article-refereed

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  • Noise and fluctuations in materials

    Jana, P. (Project Member), Koivisto, J. (Project Member), Alava, M. (Principal investigator), Zapperi, S. (Project Member), Lehtinen, A. (Project Member), Hanifpour, M. (Project Member), Korhonen, M. (Project Member), Salmenjoki, H. (Project Member) & Viitanen, L. (Project Member)

    01/09/201431/12/2018

    Project: Academy of Finland: Other research funding

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