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Abstract
Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.
Original language | English |
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Pages (from-to) | 3774-3782 |
Number of pages | 9 |
Journal | Soft Matter |
Volume | 14 |
Issue number | 19 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
MoE publication type | A1 Journal article-refereed |
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Dive into the research topics of 'From jamming to collective cell migration through a boundary induced transition'. Together they form a unique fingerprint.Projects
- 1 Finished
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Noise and fluctuations in materials
Jana, P. (Project Member), Koivisto, J. (Project Member), Alava, M. (Principal investigator), Zapperi, S. (Project Member), Lehtinen, A. (Project Member), Hanifpour, M. (Project Member), Korhonen, M. (Project Member), Salmenjoki, H. (Project Member) & Viitanen, L. (Project Member)
01/09/2014 → 31/12/2018
Project: Academy of Finland: Other research funding